2-methoxy-3-isopropylpyrazine
SMILES:
CC(C)C1=NC=CN=C1OC
Aroma Description:
green_pea, earthy, beany, chocolate, nutty1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|
| OR5K1 | -4.84 3, -6 5 | 4.9 2, 7.094 5 | hazelnut, nutty, roasted, peanut | |
| OR2AG1 | -6.7 4, -6.7 5 | 3.5294 4, 7.8632 5 | galbanum, green_pea, honey, heliotrope, banana, bell_pepper, solvent | |
| OR3A4 | - | 3.25 6 | green_pea, earthy, musty | |
| OR51S1 | - | 0 6 |
2-methoxy-3-isopropylpyrazine
SMILES:
CC(C)C1=NC=CN=C1OC
Aroma Description:
green_pea, earthy, beany, chocolate, nutty
| Receptor | Docking Score | Correlated Perceptual Qualities |
|---|
1.) The Good Scents Company
2.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.
3.) Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreißl, Jörg Stein, Alessandro Marchetto, Andreas Dunkel, Thomas Hofmann, Dietmar Krautwurst, Antonella Di Pizio Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1. bioRxiv 2022.06.01.494157; doi: https://doi.org/10.1101/2022.06.01.494157
4.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.
5.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.
6.) Son, M., D. G. Cho, J. H. Lim, J. Park, S. Hong, H. J. Ko, and Park, T. H. (2015) Real-time monitoring of geosmin and 2- methylisoborneol, representative odor compounds in water pollution using bioelectronic nose with human-like performance, Biosens. Bioelectron., 74: 199–206.