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Olfactory Receptor family 2 subfamily AG member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 

       110        120        130        140        150        160        170        180        190        200 
MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY 

       210        220        230        240        250        260        270        280        290        300 
VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 

       310        320 
LRRVLGKYML PAHSTL

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

S G S D        F  G G F S     T Y   R S T D     P L   Q R T S  
 L E P    D A L    L A C   V T Y I   L E Y   V Y M F   I N D   
T A C L  A K P T  L F M Q   L A S   V Y V M   T A A   F V S I  
 I T I    V V S    T L A   L S A L   V G M   G Y F M   I T Y   
L L Y L  T F L L  A G G M   I W S   I L F T   G V V   A P T V  
 I L A    D M L    L D E   T A V M   L S P   T L H S   P N L   
L G N S  S L Q G  F A L L   L W C   L I A A   S C T   S Y I L  
 L L L    L L L    Y A M   A R S S   Y S A   V L A K       L   
  T I A  Y M P M  V Y R D           L I Q T   K R G            
                   C I A             V T L   E N S P           
                        H               H L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
phenoxyethyl isobutyrate - 10 1  sweet, fruity, tropical, rose, honey, floral, waxy, green, apple, powdery
bean pyrazine -6.7 2 7.8632 3  green_pea, earthy, beany, chocolate, nutty
2-sec-butyl-3-methoxypyrazine -6.4 3 7.094 3  musty, green, pea, galbanum, bell, pepper
isoamyl acetate - 8.617 1  banana, fruity, solvent, sweet
galbanum pyrazine -6.1 2 6.7521 3  green_pea, bell_pepper, green, galbanum
2-ethyl pyridine -4 2 10 2  green, grassy
phenethyl acetate - 7.9787 1  floral, fruity, honey, rose, sweet, tropical
isoamyl benzoate - 7.6596 1  balsamic, green, sweet, waxy
prenyl acetate - 7.5532 1  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
n-amyl butyrate -0.65 4 10 5  sweet, fruity, banana, pineapple, cherry, tropical
earthy pyrazine -4 2 1.8803 3  raw_potato, earthy, green, bell_pepper, nutty
2-isobutyl-3-methylpyrazine -3.8 2 2.1368 3  herbal, green, sugar
2-isobutylthiazole -4.2 3 1.1966 3  green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic
shoyu pyrazine -3 3 0.6838 3  nutty, pepper, raw
androstadienone -1.5 4 0.0494 4  animal, musky
o-isopropylanisole - 0.0588 2  
acetic acid - 0 6  sharp, pungent, sour, vinegar
2-acetyl-3,5-dimethyl pyrazine - 0 3  nutty, hazelnut, roasted_hazelnut
almond pyrazine - 0 3  roasted, almond, hazelnut, peanut
butyl butyrate - 0 6  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
2,5-dimethyl pyrazine - 0 3  cocoa, nutty, roasted, beefy, woody, grassy, medicinal
2,6-dimethylpyrazine - 0 3  ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk
ethanol - 0 6  alcoholic, ethereal, fruity
3-ethyl pyridine - 0 3  tobacco, oakmoss, leathery, caramellic, roasted, hazelnut
2-ethyl-3,5-dimethylpyrazine - 0 3  almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted
filbert pyrazine - 0 3  nutty, peanut, musty, corn, raw, earthy, bready
hazelnut pyrazine - 0 3  earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable
helional - 0 6  cyclamen, fresh, green, hay, ozone, watery
hexyl butyrate - 0 6  green, sweet, fruity, apple, waxy, soapy, estery, vegetable
hydrochloric acid - 0 6  
2,4-lutidine - 0 3  smoky, phenolic
2,5-lutidine - 0 3  roasted, green, earthy
2-methoxy-3,5-dimethylpyrazine - 0 3  earthy
methyl alcohol - 0 6  alcoholic
methyl isoeugenol - 0 3  spicy, clove, floral, carnation, woody
6-methyl quinoline - 0 3  leathery, tonka, castoreum, tobacco, civet, fecal
2-methylthio-3-methylpyrazine - 0 3  roasted, meaty, nutty, almond, vegetable
phenylpropyl alcohol - 0 6  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
piperonal - 0 6  maraschino_cherry, bitter_almond, cherry, tropical, custard, vanilla, spicy, sweet, creamy, cinnamyl
propyl butyrate - 0 6  fruity, sweet, apricot, pineapple, rancid, sweaty
safrole - 0 6  anise, floral, sassafrass, spicy, sweet, warm, woody
1,2,4-trimethylbenzene - 0 3  
2,3,5-trimethylpyrazine - 0 3  nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty
2,3,5-trimethylpyridine - 0 3  
2-ethyl pyrazine -3.5 2 -0.5882 2  peanut, butter, musty, nutty, woody, roasted, cocoa, fermented, meaty

1.) Gelis L, Wolf S, Hatt H, Neuhaus EM, Gerwert K. Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1274-8. doi: 10.1002/anie.201103980. Epub 2011 Dec 5. PMID: 22144177.

2.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.

3.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) A. Mashukova, M. Spehr, H. Hatt, E.M. Neuhaus, beta-Arrestin2-Mediated Internalization of Mammalian Odorant Receptors, J. Neurosci. 26 (2006) 9902-9912.

6.) Kwon, O. S., Song, H. S., Park, S. J., Lee, S. H., An, J. H., Park, J. W., Yang, H. H., Yoon, H., Bae, J., Park, T. H. and Jang, J. (2015), An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell, Nano Lett., 15: 6559-6567.
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