Olfactory Receptor family 2 subfamily L member 13.
Estimated Expression: 88% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MEKWNHTSND FILLGLLPPN QTGIFLLCLI ILIFFLASVG NSAMIHLIHV DPRLHTPMYF LLSQLSLMDL MYISTTVPKM AYNFLSGQKG ISFLGCGVQS 110 120 130 140 150 160 170 180 190 200 FFFLTMACSE GLLLTSMAYD RYLAICHSLY YPIRMSKMMC VKMIGGSWTL GSINSLAHTV FALHIPYCRS RAIDHFFCDV PAMLLLACTD TWVYEYMVFV 210 220 230 240 250 260 270 280 290 300 STSLFLLFPF IGITSSCGRV LFAVYHMHSK EGRKKAFTTI STHLTVVIFY YAPFVYTYLR PRNLRSPAED KILAVFYTIL TPMLNPIIYS LRNKEVLGAM 310 320 RRVFGIFSFL KE
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 D E A P L V W T D A F S I G K L F T Q N P L I K N R P R Y E Y V T H A G L F N Y A F I G Y F V A L Y T V F V M L S N Q V G C M K P V L C L L L I T Y V F P S T S I S G L F F S T T S L I I L M P T A Y Y L L F L T W S M T L F I Y M L L F F I I P N F I V V F P F G G I M S C A D M L V S A Y I T L H T I G I K V C L L G E S L Q S A S N G T S I T C S S M M K S S T L L L F H I M T F A L V R G D Y A M Y M P T V H I L K K R G V A F L Y R D M H Y H C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| 1-dodecanol | -4.9 1 | 5.7143 1 | earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy | |
| caprylic acid | -4.15 2 | 1.0714 2 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| (R)-(-)-carvone | - | 3.8 2 | herbal, minty, spearmint, sweet | |
| undecanal | - | 2.8571 1 | aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy | |
| vanillin | - | 0.6 2 | chocolate, creamy, sweet, vanilla | |
| (S)-(+)-carvone | - | 0.4 2 | bready, caraway, minty, spicy | |
| geraniol | - | 0 2 | citrus, floral, fruity, rose, sweet, waxy | |
| 2-pentanone | - | 0 2 | sweet, fruity, ethereal, winey, banana, woody, fermented | |
| citronellal | - | -0.6 2 | sweet, dry, floral, herbal, waxy, aldehydic, citrus | |
| azelaic acid | - | -1 2 | ||
| eugenol | - | -1 2 | clove, spicy, sweet, woody | |
| 1-octanol | - | -1 2 | aldehydic, green, mushroom, orange, rose, waxy | |
| pyridine | - | -1 2 | ammoniacal, fishy, sour |
1.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166
2.) Morrell CN, Mix D, Aggarwal A, Bhandari R, Godwin M, Owens P 3rd, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner LE 3rd, Ashton JM, Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. J Clin Invest. 2022 May 2;132(9):e152373. doi: 10.1172/JCI152373. PMID: 35324479; PMCID: PMC9057618.