☰
 

SMILES:
[NH+](C)(C)C

Aroma Description:
ammonia, fishy, prawn1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
TAAR5 -7.52 2, -5 4, -4 5 10 2, 10 3, 10 4, 10 5  ammonia
OR1A2 - 5 6  ozone, orange, aldehydic, peel, citrus, spearmint, caraway, rose, green, tart
OR1A1 - 0 6   

SMILES:
[NH+](C)(C)C

Aroma Description:
ammonia, fishy, prawn

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

2.) Qian Li Deorphanization of Olfactory Trace Amine-Associated Receptors Chapter in Methods in Molecular Biology · June 2018 DOI: 10.1007/978-1-4939-8609-5_2

3.) Liberles SD, Buck LB. A second class of chemosensory receptors in the olfactory epithelium. Nature. 2006 Aug 10;442(7103):645-50. doi: 10.1038/nature05066. Epub 2006 Jul 30. PMID: 16878137.

4.) Wallrabenstein I, Singer M, Panten J, Hatt H, Gisselmann G. Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans. PLoS One. 2015;10(12):e0144704. Published 2015 Dec 18. doi:10.1371/journal.pone.0144704

5.) Pacalon J, Belloir C, Fiorucci S, Briand L, Topin J. TAARs response to amine are largely affected by sequence variants. Submitted.

6.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.