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Olfactory Receptor family 1 subfamily A member 2.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MKKENQSFNL DFILLGVTSQ QEQNNVFFVI FLCIYPITLT GNLLIILAIC ADIRLHNPMY FLLANLSLVD IIFSSVTIPK VLANHLLGSK FISFGGCLMQ 

       110        120        130        140        150        160        170        180        190        200 
MYFMIALAKA DSYTLAAMAY DRAVAISCPL HYTTIMSPRS CILLIAGSWV IGNTSALPHT LLTASLSFCG NQEVANFYCD IMPLLKLSCS DVHFNVKMMY 

       210        220        230        240        250        260        270        280        290        300 
LGVGVFSLPL LCIIVSYVQV FSTVFQVPST KSLFKAFCTC GSHLTVVFLY YGTTMGMYFR PLTSYSPKDA VITVMYVAVT PALNPFIYSL RNWDMKAALQ 

       310 
KLFSKRISS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

Q E Q Q     A L   G G F S     T L   H V D S       R   K P S Y  
 V N N   V K P I   M L C   L T H P   V N F   F Y M G   V A D   
I V F F   T V S   F Y M Q   L A S   Y M M K   M T T   M V T I  
 C L F   S F I I   A I M   T N G I   V G L   G Y Y L   A V Y   
I P Y I   D V L   A K A L   V W S   S F V G   F V V   A P T V  
 T L T   S L N A   Y S D   G A I L   L P L   T L H S   P N L   
L L N G   L L F   A A L T   L I C   I I C L   G C T   S Y I F  
 L I I   Y M P N   Y A M   S R P S   Y S V   C F A K           
  C I A           V A R D           F V Q V   F L S            
                   S I A             V T S   K T S P           
                        C                 F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(S)-(-)-citronellal -6.62 1 -  citrus, clean, herbal
hydroxycitronellal -6.41 1 -  floral, green, lily, melon, sweet, tropical, waxy
citral -5.83 1 -  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
(-)-carveol -5.78 2 -  minty, spearmint, cooling, green, herbal, caraway, spicy, weedy, plastic, earthy, mahogany
nerolidol - 9 2  floral, green, waxy, citrus, woody, fruity, melon
geraniol -8 1 4.5 2  citrus, floral, fruity, rose, sweet, waxy
1-octanol -5.22 1 -  aldehydic, green, mushroom, orange, rose, waxy
helional -6.47 1 6 2  cyclamen, fresh, green, hay, ozone, watery
(R)-(+)-citronellol -5.09 2 -  citronella, floral, leafy, oily, petal, rose
heptanal -6.77 1 4 2  aldehydic, cognac, fatty, fresh, green, herbal, ozone
nonanal -4.89 1 7 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
4-decenal -5.78 1 5 2  aldehydic, citrus, fatty, fresh, green, mandarin, orange, tangerine
octanal -6.37 1 4 2  aldehydic, citrus, fatty, green, orange, peel, waxy
l-limonene - 7 2  terpenic, pine, herbal, peppery
decanal - 5.5 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
(R)-(+)-citronellal - 5 2  citrus, fresh, herbal
(E),(E)-2,4-decadienal - 5 2  brothy, chicken, citrus, coriander, cucumber, fat, fatty, fried, melon, nutty, oily, pumpkin
nerol - 5 2  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
trimethylamine - 5 2  ammonia, fishy, prawn
alpha-ionone - 4 2  sweet, woody, floral, violet, orris, tropical, fruity
1-octen-3-one - 4 2  earthy, metallic, mushroom
(R)-(-)-carvone - 0 3  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 3  bready, caraway, minty, spicy
citralva - 0 2  aldehydic, citrus, lemon, metallic
citronellic acid - 0 2  green, grassy, smoky, fatty, floral, waxy, citronella, vegetable, tobacco
(S)-(-)-citronellol - 0 1  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
hexanal - 0 1  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty

1.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

2.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

3.) Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D. Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci. 2017 Nov;74(22):4209-4229. doi: 10.1007/s00018-017-2576-z. Epub 2017 Jun 27. PMID: 28656349.
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