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Olfactory Receptor family 1 subfamily A member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MRENNQSSTL EFILLGVTGQ QEQEDFFYIL FLFIYPITLI GNLLIVLAIC SDVRLHNPMY FLLANLSLVD IFFSSVTIPK MLANHLLGSK SISFGGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
MYFMIALGNT DSYILAAMAY DRAVAISRPL HYTTIMSPRS CIWLIAGSWV IGNANALPHT LLTASLSFCG NQEVANFYCD ITPLLKLSCS DIHFHVKMMY 

       210        220        230        240        250        260        270        280        290        300 
LGVGIFSVPL LCIIVSYIRV FSTVFQVPST KGVLKAFSTC GSHLTVVSLY YGTVMGTYFR PLTNYSLKDA VITVMYTAVT PMLNPFIYSL RNRDMKAALR 

       310 
KLFNKRISS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

Q E Q Q     A L   G G F S     T L   H I D S       R   K L S Y  
 F D E   M K P I   T L C   L T H P   V H F   F Y T G   V A D   
L I Y F   T V S   F Y M Q   L A N   Y M M K   M V T   M V T I  
 F L F   S F F I   A I M   A N G I   V G L   G Y Y L   A T Y   
I P Y I   D V L   T N G L   V W S   S F I G   S V V   M P T V  
 I L T   S L N A   Y S D   G A I L   L P V   T L H S   P N L   
L L N G   L L F   A A L I   W I C   I I C L   G C T   S Y I F  
 L V I   Y M P N   Y A M   S R P S   Y S V   S F A K           
  C I A           V A R D           F V R I   L V G            
                   S I A             V T S   K T S P           
                        R                 F                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
(S)-(+)-carvone -8.54 1 9.6 2  bready, caraway, minty, spicy
geraniol -8 3 9.7 2  citrus, floral, fruity, rose, sweet, waxy
dihydrojasmone -7.24 2 9.8 2  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
(S)-(-)-citronellal -6.66 3 -  citrus, clean, herbal
hydroxycitronellal -6.25 3 -  floral, green, lily, melon, sweet, tropical, waxy
(R)-(-)-carvone -6.15 4 10 5  herbal, minty, spearmint, sweet
(-)-carveol -5.79 6 -  minty, spearmint, cooling, green, herbal, caraway, spicy, weedy, plastic, earthy, mahogany
3-octanone -5.4 2 9.7 2  fresh, herbal, lavender, mushroom, sweet
3-methyl-2,4-nonanedione -5.16 7 10 8  burnt, caramellic, fruity, hay
3-heptanone -5.29 2 9.5 2  fatty, fruity, green
allyl phenylacetate -5.12 2 9.7 2  honey, fruity, rummy
benzophenone -5 9 9.6 2  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
1-octanol -5.42 3 -  aldehydic, green, mushroom, orange, rose, waxy
(S)-(-)-citronellol -5.03 3 9 2  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
2-heptanone -4.4 2 9.8 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
benzyl acetate -5 1 8.7 2  sweet, floral, fruity, jasmine, fresh
(+)-dihydrocarvone -4.99 2 8.7 2  herbal, minty, mentholic
(Z)-3-hexen-1-ol -4.05 11 10 11  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent
(R)-(+)-citronellol -5.08 6 -  citronella, floral, leafy, oily, petal, rose
(R)-3-mercapto-3-methylhexan-1-ol -4.96 12 8 12  passionfruit, currant, blackcurrant, green, fruity
2-octanone -4.37 2 8.9 2  earthy, herbal, natural, weedy, woody
helional -6.59 3 5 6  cyclamen, fresh, green, hay, ozone, watery
heptanal -6.49 3 5 6  aldehydic, cognac, fatty, fresh, green, herbal, ozone
4-chromanone -3.34 2 9.8 2  
allyl heptanoate -3.32 2 9.8 2  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
2-phenylethanethiol -4.72 7 -  rubbery, sulfurous
(E)-anethole -4.7 7 -  sweet, anise, licorice, mimosa, medicinal, spicy
2-pentylpyridine -4.67 7 -  fatty, tallow, green, bell_pepper, mushroom, herbal
2-nonanone -4.33 7 8 2  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
estragole -4.62 7 -  sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
phenethyl acetate -4.56 7 -  floral, fruity, honey, rose, sweet, tropical
ethylphenyl acetate -4.54 7 -  anisic, balsamic, black, chocolate, cocoa, dark, floral, honey, licorice, rose, sweet
nonanethiol -3.24 2 9.3 2  
p-cresyl acetate -3.4 13 9 13  narcissus, phenolic, animal
nonanal -5.26 3 6 6  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
gamma-nonalactone -4.46 7 -  buttery, coconut, creamy, oily, sweet, waxy
octanal -6.41 3 4 6  aldehydic, citrus, fatty, green, orange, peel, waxy
ethyl caproate -4.45 7 -  banana, fruity, green, pineapple, sweet, waxy
octanethiol -3.23 2 9 2  sulfurous
3-mercaptohexyl acetate -4.42 7 -  floral, fruity, pear, tropical, passionfruit, blackberry, raspberry, blackcurrant_bud
nerolidol - 7 6  floral, green, waxy, citrus, woody, fruity, melon
1-heptanol -3.01 2 9 2  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
1-octen-3-ol -4.24 7 -  mushroom
phenethyl alcohol -4.3 11 6.6667 11  floral, rose, dried_rose, sweet, fresh, bready, honey
ethyl cyclohexanecarboxylate -4.22 7 -  cheesy, fruity, winey
4-decenal -5.6 3 4.5 6  aldehydic, citrus, fatty, fresh, green, mandarin, orange, tangerine
1-decanol -3.08 2 8.5 2  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
musk ambrette -2.71 14 9.0299 14  ambrette, musty, seedy, sweet
d-limonene -4.73 7 5.3333 10  citrus, orange, fresh, sweet
ethyl 2-(3-bromophenyl)acetate -4.8 9 5 9  
methyl (2-methylphenyl)acetate -4.8 9 4.5833 9  
(E),(E)-2,4-decadienal - 6 6  brothy, chicken, citrus, coriander, cucumber, fat, fatty, fried, melon, nutty, oily, pumpkin
3-octen-2-one - 6 15  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
l-limonene -4.61 7 4 6  terpenic, pine, herbal, peppery
3-methyl-2-hexenoic acid -3.92 12 4.6 12  cheesy, fruity
citral -5.79 3 1 10  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
nerol - 5 6  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
(S)-3-mercapto-3-methylhexan-1-ol -4.96 12 1 12  passionfruit, currant, blackcurrant, green, fruity
4-vinylguaiacol -4.3 16 2 16  spicy, clove, carnation, phenolic, peppery, smoky, woody, powdery
(R)-(+)-citronellal - 4 6  citrus, fresh, herbal
decanal - 4 6  sweet, aldehydic, waxy, orange_peel, citrus, floral
quinoline - 3.6667 10  earthy, medicinal, musty, rubbery, tobacco
celestolide - 3.2 17  ambergris, animal, cedar, musk, woody
linalool -3.4 18 0.7059 18  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
para-anisaldehyde -3.3 18 0.8235 18  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
oranger crystals -3.3 18 0.8235 18  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
caproic acid -1.67 19 3.3333 19  cheesy, fatty, sour, sweaty
1-octen-3-one - 3 6  earthy, metallic, mushroom
musk tibetene -2.45 14 1.9403 14  fatty, musk, powdery, sweet
musk xylene - 2.6119 14  dry, fatty, musk, soapy, sweet
cosmone - 2 17  ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
muscenone - 0.8 17  animal, musk, soapy
musk ketone - 0.4 17  dry, fatty, floral, musk, powdery, soapy
acetophenone - 0 2  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allylbenzene - 0 2  
ambrettolide - 0 17  sweet, soapy, musk, amber, fruity, berry
butyl butyryl lactate - 0 2  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
(-)-camphor - 0 2  
camphor - 0 2  camphoraceous
capric acid - 0 2  citrus, fatty, rancid, sour
gamma-caprolactone - 0 2  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 2  cheesy, fatty, oily, rancid, vegetable, waxy
cashmeran - 0 17  spicy, musk, woody, clean
cinnamyl acetate - 0 7  sweet, floral, spicy, balsamic, cinnamon
citralva - 0 6  aldehydic, citrus, lemon, metallic
citronellic acid - 0 6  green, grassy, smoky, fatty, floral, waxy, citronella, vegetable, tobacco
coffee difuran - 0 10  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 2  
coumarin - 0 10  coumarinic, hay, sweet, tonka
p-cresol - 0 13  phenolic, narcissus, animal, mimosa
cyclodecanone - 0 17  
cyclohexanone - 0 2  acetone, minty
cyclopentadecane - 0 17  
cyclopentadecanol - 0 17  musk
cyclopentadecanone - 0 17  animal, greasy, musk, natural, powdery
cycloundecanone - 0 17  
ethyl isobutyrate - 0 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
ethylene brassylate - 0 17  ambrette, floral, musk, powdery, sweet, woody
eugenol - 0 10  clove, spicy, sweet, woody
eugenyl acetate - 0 10  carnation, clove, floral, fresh, malty, spicy, sweet, woody
fenchone - 0 2  camphoraceous, earthy, herbal, woody
galaxolide - 0 17  floral, musk, sweet
globanone - 0 17  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
habanolide - 0 17  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
helvetolide - 0 17  musk, ambrette, fruity, pear, woody, floral
2-heptanol - 0 7  floral, fresh, fruity, green, herbal, lemongrass, sweet
(E)-2-heptenal - 0 7  pungent, green, vegetable, fresh, fatty
hexanal - 0 2  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 2  buttery, sweet
3,4-hexanedione - 0 2  almond, buttery, caramellic, nutty, toasted
1-hexanol - 0 2  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 2  ethereal
hexyl acetate - 0 2  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 2  
alpha-ionone - 0 6  sweet, woody, floral, violet, orris, tropical, fruity
isoamyl acetate - 0 7  banana, fruity, solvent, sweet
(+)-menthol - 0 10  cooling, mentholic, minty
4-methyl acetophenone - 0 7  hawthorn, sweet, mimosa, coumarinic, cherry, acacia
methyl cinnamate - 0 7  balsamic, cherry, strawberry, sweet
methyl eugenol - 0 10  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 10  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
3-methylcyclotetradecanone - 0 17  
muscone - 0 17  musk, animal, powdery
1-nonanol - 0 10  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
gamma-octalactone - 0 7  sweet, coconut, waxy, creamy, tonka, dairy, fatty
oenanthic acid - 0 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
oxacyclohexan-2-one - 0 17  
p,alpha-dimethylstyrene - 0 7  clove, guaiacol, phenolic, spicy, styrene
2-pentadecanone - 0 17  burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone - 0 17  
2-pentanone - 0 2  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 2  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 2  
prenyl acetate - 0 2  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
sotolone - 0 10  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
tonalide - 0 17  amber, ambrette, fruity, musk, powdery, sweet
trimethylamine - 0 6  ammonia, fishy, prawn
valeric acid - 0 2  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 2  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
velvione - 0 17  dry, powdery, musk, amber, civet
lyral - -0.5 10  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
pelargonic acid - -1 10  cheesy, dairy, dirty, waxy
amyl hexanoate - -1.1667 10  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
dimethyl disulfide - -1.1667 10  sulfurous, vegetable, cabbage, onion, malty, creamy
geranyl acetate - -1.1667 10  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
terpinyl acetate - -1.2 10  bergamot, citrus, herbal, lavender, lime
propionic acid - -1.2333 10  acidic, cheesy, pungent, vinegar
butyric acid - -1.2667 10  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
2,4-DNT - -1.2667 10  
butyl formate - -1.3 10  fruity, plum, rummy, brandy
beta-damascone - -1.3333 10  berry, currant, floral, fruity, honey, plum, rose, tobacco
methyl salicylate - -1.3333 10  minty, wintergreen
octyl octanoate - -1.3333 10  coconut, oily, fruity
androstenone - -1.4333 10  animal, musky
isobutylamine - -1.5 10  cheesy, fishy
l-arabinose - -1.5667 10  
ethyl vanillin - -1.5667 10  sweet, creamy, vanilla, caramellic
propanal - -1.5667 10  alcoholic, cocoa, earthy, nutty, whiskey, winey
pyrazine - -1.5667 10  pungent, sweet, corn, roasted, hazelnut, barley
1,10-phenanthroline -3.9 9 -1.6667 9  
benzene - -1.6667 10  
2-ethyl fenchol - -1.6667 10  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
pentanol - -1.6667 10  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent

1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

2.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

3.) Silva Teixeira CS, Silva Ferreira AC, Cerqueira NM. Studying Haloanisoles Interaction with Olfactory Receptors. ACS Chem Neurosci. 2016 Jul 20;7(7):870-85. doi: 10.1021/acschemneuro.5b00335. Epub 2016 May 9. PMID: 27092849.

4.) Saito N, Yamano E, Ishii A, Tanaka M, Nakamura J, et al. (2018) Involvement of the olfactory system in the induction of anti-fatigue effects by odorants. PLOS ONE 13(3): e0195263. https://doi.org/10.1371/journal.pone.0195263

5.) Geithe C, Protze J, Kreuchwig F, Krause G, Krautwurst D. Structural determinants of a conserved enantiomer-selective carvone binding pocket in the human odorant receptor OR1A1. Cell Mol Life Sci. 2017 Nov;74(22):4209-4229. doi: 10.1007/s00018-017-2576-z. Epub 2017 Jun 27. PMID: 28656349.

6.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

7.) Christiane Geithe, Franziska Noe, Johanna Kreissl, Dietmar Krautwurst, The Broadly Tuned Odorant Receptor OR1A1 is Highly Selective for 3-Methyl-2,4-nonanedione, a Key Food Odorant in Aged Wines, Tea, and Other Foods, Chemical Senses, Volume 42, Issue 3, 1 March 2017, Pages 181–193, https://doi.org/10.1093/chemse/bjw117

8.) Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9. PMID: 35944068.

9.) Jabeen A, de March CA, Matsunami H, Ranganathan S. Machine Learning Assisted Approach for Finding Novel High Activity Agonists of Human Ectopic Olfactory Receptors. International Journal of Molecular Sciences. 2021; 22(21):11546. https://doi.org/10.3390/ijms222111546

10.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

11.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1

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13.) Shirai, T., Takase, D., Yokoyama, J. et al. Functions of human olfactory mucus and age-dependent changes. Sci Rep 13, 971 (2023). https://doi.org/10.1038/s41598-023-27937-1

14.) Ahmed, Lucky et al "Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds." Proceedings of the National Academy of Sciences 115.17 (2018): E3950-E3958. Web. 29 Aug. 2021.

15.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147

16.) Aya Namba, Naoko Saito, Keiichi Yoshikawa, Ichiro Mori (2015) Search method of urine odor suppressor JP2015211667A

17.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016

18.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

19.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
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