eugenol methyl ether
SMILES:
COc1cc(ccc1OC)CC=C
Aroma Description:
carnation, cinnamon, clove, fresh, spicy, sweet, warm1
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR2J2 | 92 | -7 2 | - | tart, sweet, carnation, hay, orange, warm, cinnamon, clove, coumarinic | |
| OR5K1 | 100 | -8 2, -3.52 3, -5.21 6, -8.22 7 | - | hazelnut, nutty, peanut, roasted, carnation, cocoa, almond | |
| OR10G7 | 80 | -6 2 | - | vanilla, clove, carnation, spicy, smoky | |
| OR2J3 | 100 | - | 1.9 3 | tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy | |
| OR51E1 | 100 | - | 1.1667 3 | cheesy, sour, sweaty, sharp, acidic, dairy | |
| OR5K4 | 57 | - | 0.9333 3 | (insufficient data) | |
| OR7D4 | 96 | - | 0.3 4 | animal, citrus, orange, peely, tart, aldehydic, blueberry | |
| OR5K2 | 100 | - | 0.2333 3 | (insufficient data) | |
| OR5K3 | 92 | - | 0.1333 3 | (insufficient data) | |
| OR10G3 | 96 | - | 0 3 | ||
| OR10J5 | 84 | - | 0 3 | ||
| OR11A1 | 100 | - | 0 3 | ||
| OR1A1 | 73 | - | 0 3 | ||
| OR1C1 | 100 | - | 0 3 | ||
| OR2A25 | 100 | - | 0 3 | ||
| OR2B11 | 100 | - | 0 3 | ||
| OR2W1 | 53 | - | 0 3 | ||
| OR51L1 | 88 | - | 0 3 | ||
| OR56A4 | 100 | - | 0 3 | ||
| OR8D1 | 96 | - | 0 3 | ||
| OR8K3 | 92 | - | 0 3 | ||
| OR5P3 | 100 | - | -2.5 3 |
eugenol methyl ether
SMILES:
COc1cc(ccc1OC)CC=C
Aroma Description:
carnation, cinnamon, clove, fresh, spicy, sweet, warm
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
4.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
5.) Marcinek, Patrick, et al. "An evolutionary conserved olfactory receptor for foodborne and semiochemical alkylpyrazines." The FASEB Journal 35.6 (2021): e21638.
6.) Alessandro Nicoli, Franziska Haag, Patrick Marcinek, Ruiming He, Johanna Kreißl, Jörg Stein, Alessandro Marchetto, Andreas Dunkel, Thomas Hofmann, Dietmar Krautwurst, Antonella Di Pizio Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1. bioRxiv 2022.06.01.494157; doi: https://doi.org/10.1101/2022.06.01.494157
7.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.