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Olfactory Receptor family 7 subfamily D member 4.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEAENLTELS KFLLLGLSDD PELQPVLFGL FLSMYLVTVL GNLLIILAVS SDSHLHTPMY FFLSNLSFVD ICFISTTVPK MLVSIQARSK DISYMGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
VYFLMMFAGM DTFLLAVMAY DRFVAICHPL HYTVIMNPCL CGLLVLASWF IIFWFSLVHI LLMKRLTFST GTEIPHFFCE PAQVLKVACS NTLLNNIVLY 

       210        220        230        240        250        260        270        280        290        300 
VATALLGVFP VAGILFSYSQ IVSSLMGMSS TKGKYKAFST CGSHLCVVSL FYGTGLGVYL SSAVTHSSQS SSTASVMYAM VTPMLNPFIY SLRNKDVKGA 

       310        320 
LERLLSRADS CP

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


S S Q S    L Y V  L L T N     M L   S I D K      Q I  L E P D  
 A T S    G L G    I N N   L I H V   G M Y    S V L    V P Q   
Y M V S  T G Y F  V Y L V   L S F   Q T L C  M K P V  L G F L  
 V M A    L S V    A T A   W F I I   F Y V    T T S    S L F   
L M P T  V C L H  V G L L   F W S   F M M L  I F C I  V L Y M  
 F P N    S G C    V P F   A L V L   M G A    D V F    L V T   
L S Y I  T S F A  L I G A   L G C   L F T D  S L N S  L L N G  
     R    K Y K    Y S F   L C P N   V A L    L F F    L I I   
         G K T S  V I Q S           D Y A M  Y M P T  S S V A  
                   L S S             V F R                 D   
                    M G M           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
androstenone -6.89 1 10 1  animal, musky
androstadienone -6.54 2 9 2  animal, musky
(R)-(-)-carvone - 0.4 2  herbal, minty, spearmint, sweet
geranyl acetate - 0.4 2  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
octanal - 0.4 2  aldehydic, citrus, fatty, green, orange, peel, waxy
butyl acetate - 0.3 2  ethereal, solvent, fruity, banana
eucalyptol - 0.3 2  camphorous, eucalyptus, herbal
guaiacol - 0.3 2  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty
(Z)-3-hexen-1-ol - 0.3 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutyraldehyde - 0.3 2  cereal, malty
d-limonene - 0.3 2  citrus, orange, fresh, sweet
methyl eugenol - 0.3 2  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl salicylate - 0.3 2  minty, wintergreen
octyl acetate - 0.3 2  apple, earthy, fruity, green, herbal, mushroom, waxy
pyrazine - 0.3 2  pungent, sweet, corn, roasted, hazelnut, barley
bourgeonal - 0.2 2  fresh, watery, floral, cyclamen, sweet
n-butyl alcohol - 0.2 2  fusel, oily, sweet, balsamic, whisky, banana
butyric acid - 0.2 2  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
caproic acid - 0.2 2  cheesy, fatty, sour, sweaty
cinnamaldehyde - 0.2 2  sweet, spicy, candy, cinnamon, warm
citral - 0.2 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
creosol - 0.2 2  burnt, clove, leathery, medicinal, phenolic, smoky, spicy, vanilla, woody
diphenyl ether - 0.2 2  geranium, green, leafy, phenolic
2-ethyl fenchol - 0.2 2  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0.2 2  sweet, creamy, vanilla, caramellic
ethylene brassylate - 0.2 2  ambrette, floral, musk, powdery, sweet, woody
eugenol - 0.2 2  clove, spicy, sweet, woody
eugenyl acetate - 0.2 2  carnation, clove, floral, fresh, malty, spicy, sweet, woody
exaltolide - 0.2 2  animal, fruity, musk, natural, powdery
galaxolide - 0.2 2  floral, musk, sweet
heptanal - 0.2 2  aldehydic, cognac, fatty, fresh, green, herbal, ozone
heptyl acetate - 0.2 2  aldehydic, apricot, citrus, fatty, fresh, fruit, green, pear, ripe, rummy, waxy, winey, woody
isobutyric acid - 0.2 2  acidic, buttery, cheesy, dairy, rancid, sour
isoeugenol - 0.2 2  carnation, clove, floral, spicy, sweet, woody
isovaleric acid - 0.2 2  cheesy, sour, sweaty, tropical
linalool - 0.2 2  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1R,2S,5R)-(-)-menthol - 0.2 2  peppermint, cooling, mentholic, minty, camphorous, clean, fresh, sweet, herbal
(1S,2R,5S)-(+)-menthol - 0.2 2  cooling, mentholic, minty, fresh, sweet, herbal
methanethiol - 0.2 2  alliaceous, cabbage, cheesy, creamy, eggy, garlic, meaty, oily, vegetable
4-methylvaleric acid - 0.2 2  cheesy, pungent
nonanal - 0.2 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
phenylacetaldehyde - 0.2 2  clover, cocoa, floral, green, honey, hyacinth, sweet
alpha-terpineol - 0.2 2  pine, terpenic, lilac, citrus, woody, floral, resinous, cooling, lemon, lime
terpinyl acetate - 0.2 2  bergamot, citrus, herbal, lavender, lime
vanillin - 0.2 2  chocolate, creamy, sweet, vanilla
2-butanone - 0.1 2  acetone, ethereal, fruity, camphorous, chemical, green
decanal - 0.1 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
2-decenal - 0.1 2  waxy, fatty, earthy, green, cilantro, mushroom, aldehydic, fried, chicken_fat, tallow
diacetyl - 0.1 2  buttery, caramellic, creamy, pungent, sweet
diallyl sulfide - 0.1 2  sulfurous, onion, garlic, horseradish, metallic, pungent
fenchone - 0.1 2  camphorous, earthy, herbal, woody
hexyl butyrate - 0.1 2  green, sweet, fruity, apple, waxy, soapy, estery, vegetable
isobornyl acetate - 0.1 2  balsamic, camphorous, herbal, woody, sweet, citrus, soapy, terpenic, pine
undecanal - 0.1 2  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
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