Names:
guaiacol, O-methylcatechol
SMILES:
COc1ccccc1O
Aroma Description:
phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty1
woody, balsamic, sweet, smoky, phenolic, burnt2
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR10G4 | 88 | -7.7 7 | 10 7 | vanilla, carnation, clove, smoky | |
| OR10G7 | 80 | -6 3, -2.4 4 | 8.1972 3, 5 4 | vanilla, clove, carnation, smoky, spicy | |
| OR1G1 | 61 | - | 5.3299 5 | waxy, sweet, citrus, tart, fresh, orange, aldehydic, fatty, rose, floral | |
| OR10G9 | 46 | -2.49 4 | 3.75 4 | vanilla | |
| OR52D1 | 100 | - | 1.269 5 | dairy, cheesy, anise, creamy, peach, sweet, fatty, milky, orange, lactonic | |
| OR7D4 | 96 | - | 0.3 6 | animal |
O-methylcatechol
SMILES:
COc1ccccc1O
Aroma Description:
phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meatywoody, balsamic, sweet, smoky, phenolic, burnt
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) https://primaryodors.org/
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
5.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
6.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
7.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120