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Olfactory Receptor family 52 subfamily D member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSDSNLSDNH LPDTFFLTGI PGLEAAHFWI AIPFCAMYLV ALVGNAALIL VIAMDNALHA PMYLFLCLLS LTDLALSSTT VPKMLAILWL HAGEISFGGC 

       110        120        130        140        150        160        170        180        190        200 
LAQMFCVHSI YALESSILLA MAFDRYVAIC NPLRYTTILN HAVIGRIGFV GLFRSVAIVS PFIFLLRRLP YCGHRVMTHT YCEHMGIARL ACANITVNIV 

       210        220        230        240        250        260        270        280        290        300 
YGLTVALLAM GLDSILIAIS YGFILHAVFH LPSHDAQHKA LSTCGSHIGI ILVFYIPAFF SFLTHRFGHH EVPKHVHIFL ANLYVLVPPV LNPILYGART 

       310        320 
KEIRSRLLKL LHLGKTSI

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


H K P V       G   V T I N     L L   S I E G      L W  A A E L  
 I H V   F R H T   V I N   F I F P   G G F    L I A    W F H   
N A L F   L F S   T L G Y   S V I   Q A L C  L M K P  P I A I  
 V Y L   F F A P   L A V   A V S R   C F M    V T T    A C F   
P P V L   I Y F   G M A L   F L G   I S H V  S S L A  V L Y M  
 N L V   V L I I   S D L   V F G I   L A Y    L D T    V L A   
Y L I P   G I H   A I L I   R G I   I S S E  L S L L  A A N G  
   A G   S G C T   Y S I   V A H N   A L L    C L F    L I L   
          S L A   L I F G           D F A M  L Y M P  M A I V  
         K H Q A   V A H             V Y R                 D   
                    L H F             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
delta-decalactone - 8.3333 1  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
isoamyl acetate - 4.7716 2  banana, fruity, solvent, sweet
benzyl alcohol - 4.5685 2  floral, rose, phenolic, balsamic
1-nonanol - 4.5685 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
3-nonanone - 4.5685 2  floral, fresh, fruity, herbal, jasmine, leafy, spicy, sweet
sulcatone - 4.5685 2  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
2-decanone - 4.4162 2  cheesy, fatty, fermented, floral, orange, peach
2-nonanol - 4.4162 2  waxy, green, creamy, citrus, orange, cheesy, fruity
acetophenone - 4.3655 2  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
benzothiazole - 4.264 2  sulfurous, rubbery, vegetable, cooked, nutty, coffee, meaty, brown
methyl caprylate -1.09 2 6.599 2  aldehydic, green, herbal, orange, sweet, vegetable, waxy
butyl butyrate - 4.1624 2  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
ethyl oenanthate - 4.1624 2  fruity, pineapple, cognac, rummy, winey
estragole - 4.1117 2  sweet, sassafrass, anise, spicy, green, herbal, fennel, phenolic, minty
ethyl caproate - 4.0609 2  banana, fruity, green, pineapple, sweet, waxy
beta-ionone - 4.0609 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
oenanthic acid - 4.0609 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
citralva - 3.9594 2  aldehydic, citrus, lemon, metallic
caprylic acid - 3.9086 2  cheesy, fatty, oily, rancid, vegetable, waxy
3-octanone - 3.8071 2  fresh, herbal, lavender, mushroom, sweet
methyl oenanthate - 3.7563 2  sweet, fruity, green, orris, waxy, floral, berry, apple
citral - 3.5533 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
octanal - 3.5533 2  aldehydic, citrus, fatty, green, orange, peel, waxy
S-methyl thiobutanoate - 3.5025 2  cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato
(E)-anethole - 3.4518 2  sweet, anise, licorice, mimosa, medicinal, spicy
thiazole - 3.4518 2  fishy, nutty, meaty
cyclohexanone - 3.1472 2  acetone, minty
anisole - 3.0964 2  phenolic, gasoline, ethereal, anise
safrole - 3.0964 2  anise, floral, sassafrass, spicy, sweet, warm, woody
benzaldehyde - 3.0457 2  sharp, sweet, bitter, almond, cherry
decanal - 2.9949 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
(E)-cinnamic acid - 2.9442 2  balsamic, cinnamyl, storax, sweet
galbanum pyrazine - 2.9442 2  green_pea, bell_pepper, green, galbanum
acetoin - 2.8934 2  sweet, buttery, creamy, dairy, milky, fatty
butyric acid - 2.8934 1  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
ethyl butyrate - 2.8934 2  cognac, fruit, fruity, juicy, pineapple
pelargonic acid - 2.8934 2  cheesy, dairy, dirty, waxy
isovaleric acid - 2.8426 2  cheesy, sour, sweaty, tropical
cinnamaldehyde - 2.7919 2  sweet, spicy, candy, cinnamon, warm
isobutyric acid - 2.7919 2  acidic, buttery, cheesy, dairy, rancid, sour
para-anisaldehyde - 2.6396 2  sweet, powdery, mimosa, floral, hawthorn, balsamic, vanilla, anise, woody, coumarinic, creamy, spicy
caproic acid - 2.6396 2  cheesy, fatty, sour, sweaty
propionic acid - 2.5381 2  acidic, cheesy, pungent, vinegar
helional - 2.3858 2  cyclamen, fresh, green, hay, ozone, watery
nonanal - 2.3858 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
methyl salicylate - 2.132 2  minty, wintergreen
undecanal - 2.132 2  aldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
dimethyl disulfide - 1.9289 2  sulfurous, vegetable, cabbage, onion, malty, creamy
piperonyl acetone - 1.8782 2  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
lauric aldehyde - 1.7766 2  aldehydic, citrus, floral, green, soapy, waxy
methyl caproate - 1.7766 2  apricot, bacon, banana, ethereal, fruit, fruity, pineapple, strawberry, tropical
methyl decanoate - 1.7259 2  oily, winey, fruity, floral, fatty
eucalyptol - 1.6751 2  camphorous, eucalyptus, herbal
ethyl decanoate - 1.6244 2  apple, brandy, fruity, grape, oily, sweet, waxy
hedione - 1.6244 2  floral, oily, jasmine, green, lactonic, tropical, natural, sweet, fruity, citrus, lemon, grapefruit, woody
2-nonanone - 1.6244 2  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
hexanol - 1.5228 2  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-octanone - 1.3706 2  earthy, herbal, natural, weedy, woody
4-octanol - 1.3198 2  
pyrazine - 1.3198 2  pungent, sweet, corn, roasted, hazelnut, barley
camphor - 1.269 2  camphorous
ethyl pelargonate - 1.269 2  fruity, natural, rose, rummy, tropical, waxy, winey
2-ethyl-1-hexanol - 1.269 2  citrus, fresh, floral, oily, sweet, fatty, fruity
geranyl acetate - 1.269 2  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
guaiacol - 1.269 2  phenolic, smoky, spicy, vanilla, woody, medicinal, savory, meaty
lyral - 1.269 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
2-methyl pyrazine - 1.2183 2  nutty, cocoa, roasted, chocolate, peanut, green, brown, nut_skin, musty, earthy
methyl pelargonate - 1.1675 2  fruity, pear, sweet, tropical, waxy, winey
1-octanol - 1.1675 2  aldehydic, green, mushroom, orange, rose, waxy
(S)-(-)-citronellal - 1.1168 2  citrus, clean, herbal
citronellal - 1.1168 2  sweet, dry, floral, herbal, waxy, aldehydic, citrus
heptanal - 1.1168 3  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 1.1168 2  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone - 1.0152 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
maltol - 1.0152 2  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
coumarin - 0.9645 2  coumarinic, hay, sweet, tonka
menthone - 0.9137 2  minty
ethyl vanillin - 0.7614 2  sweet, creamy, vanilla, caramellic
geraniol - 0.7614 2  citrus, floral, fruity, rose, sweet, waxy
2-octanol - 0.7614 2  fresh, spicy, green, woody, herbal, earthy, nasturtium, banana, unripe_banana, mushroom
pyridine - 0.6599 2  ammoniacal, fishy, sour
ethyl isobutyrate - 0.6091 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
quinoline - 0.6091 2  earthy, medicinal, musty, rubbery, tobacco
vanillin - 0.5076 2  chocolate, creamy, sweet, vanilla
indole - 0.4569 2  animal, fecal, floral, naphthyl
d-limonene - 0.4569 2  citrus, orange, fresh, sweet
capric acid - 0.2538 2  citrus, fatty, rancid, sour
(1S,2R,5S)-(+)-menthol - 0.2538 2  cooling, mentholic, minty, fresh, sweet, herbal
gamma-decalactone - 0.203 2  fresh, oily, waxy, peach, coconut, buttery, sweet
1-decanol - 0.203 2  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
1-dodecanol - 0.1015 2  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
ethyl caprylate - 0.1015 2  fruity, winey, waxy, sweet, apricot, banana, brandy, pear, musty, pineapple, creamy, dairy
3-octanol - 0.1015 2  earthy, mushroom, herbal, melon, citrus, woody, spicy, minty, dairy, musty, creamy, waxy, fermented, green
lauric acid - 0.0761 2  bay, coconut, fatty
hexanal - 0.0508 2  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
thymol - 0.0508 2  camphorous, herbal, medicinal, phenolic, thyme
diacetyl - 0 1  buttery, caramellic, creamy, pungent, sweet

1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

2.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

3.) Lim J. H., J. Park, E. H. Oh, H. J. Ko, S. Hong, and Park, T. H. (2014) Nanovesicle-based bioelectronic nose for the diagnosis of lung cancer from human blood. Adv. Healthcare Mater., 3: 360–366.

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