tert-butanethiol, 2-methyl-2-propanethiol
SMILES:
C(C)(C)(C)S
Aroma Description:
skunk, sulfurous1
Notes:
Emter et al (2025) report that freshly prepared thiols do not activate OR2T11, while aged thiol solutions do, owing to the formation of disulfides which they report OR2T11 is selectively sensitive to.
tert-butanethiol, 2-methyl-2-propanethiol
SMILES:
C(C)(C)(C)S
Aroma Description:
skunk, sulfurous
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) Shengju Li, Lucky Ahmed, Ruina Zhang, Yi Pan, Hiroaki Matsunami, Jessica L. Burger, Eric Block, Victor S. Batista, and Hanyi Zhuang Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols Journal of the American Chemical Society 2016 138 (40), 13281-13288 DOI: 10.1021/jacs.6b06983
3.) Block, Batista, Matsunami, Zhuang, Ahmed The role of metals in mammalian olfaction of low molecular weight organosulfur compound Nat. Prod. Rep., 2017,34, 529-557
4.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
5.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1