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Olfactory Receptor family 2 subfamily T member 11.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MTNTSSSDFT LLGLLVNSEA AGIVFTVILA VFLGAVTANL VMIFLIQVDS RLHTPMYFLL SQLSIMDTLF ICTTVPKLLA DMVSKEKIIS FVACGIQIFL 

       110        120        130        140        150        160        170        180        190        200 
YLTMIGSEFF LLGLMAYDCY VAVCNPLRYP VLMNRKKCLL LAAGAWFGGS LDGFLLTPIT MNVPYCGSRS INHFFCEIPA VLKLACADTS LYETLMYICC 

       210        220        230        240        250        260        270        280        290        300 
VLMLLIPISI ISTSYSLILL TIHRMPSAEG RKKAFTTCSS HLTVVSIFYG AAFYTYVLPQ SFHTPEQDKV VSAFYTIVTP MLNPLIYSLR NKDVIGAFKK 

       310        320 
VFACCSSAQK VATSDA

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D Q E P       F   L S T D     T I   S I I K      V M  A E S N  
 V V K   S Q P L   T E Y   P T L L   A V F    D A L    I G A   
Y F A S   V Y T   I Y M L   F G D   Q I G C  L K P V  V T F V  
 V I T   Y F A A   V C C   L S G G   L F I    T T C    A L I   
L M P T   G Y F   L L M L   F W A   M T L Y  I F L T  G L F V  
 L P N   I S V V   I P I   G A A L   S G I    D M I    T V A   
    Y I   T L H   S I I S   L L C   L F F E  S L Q S  V L N A  
         S S C T   Y S T   K K R N   L G L    L L F    F I M   
          T F A   L I L S           D Y A M  Y M P T  V Q I L  
         K K R G   I T L             V Y C                 D   
                    M R H           N C V A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
hydrogen sulfide - 10 1  egg, sulfurous
tert-butyl mercaptan -4.9 1 10 1  skunk, sulfurous
di-tert-butyl disulfide -5.09 2 -  garlic, green_onion, sulfurous
diallyl disulfide -5.49 1 7.5 1  alliaceous, garlic, metallic, onion
isopropanethiol -5.1 3 7.5 3  brothy, chicken, gassy, meaty, onion, ripe, sulfurous
methyl furfuryl disulfide -4.42 2 -  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
dipropyl disulfide -5.02 1 5.9 1  sulfurous, earthy, burnt, onion, green_onion
cyclopentanethiol - 6.9 1  alliaceous, celery, eggy, garlic, horseradish, meaty, onion, vegetable
2-butanethiol -5.1 3 5 3  sulfurous
ethanethiol -4.7 3 5 3  cabbage, onion, sulfurous
isobutyl mercaptan -5 3 4 3  cooked, mustard, sulfurous, vegetable
allyl mercaptan -5.8 2 2 2  alliaceous, sulfurous, garlic, onion, roasted, cooked_onion, grilled, charred, meaty
propanethiol -5.2 3 2.8 3  cabbage, gassy, sweet, onion
3-methyl-2-butanethiol -4.6 3 1.7 3  beefy, meaty, sulfurous, savory, burnt, rubbery, roasted, chicken, pork, coffee, roasted_coffee, cheesy
3-mercapto-3-methylbutyl formate - 4 1  catty, blackcurrant
methanethiol - 3.913 4  alliaceous, cabbage, cheesy, creamy, eggy, garlic, meaty, oily, vegetable
2-acetylthiazole - 3.5 1  nutty, popcorn, peanut, roasted, hazelnut, toasted, corn_chip, raw, bready
dimethyl disulfide - 3.1 1  sulfurous, vegetable, cabbage, onion, malty, creamy
S-methyl thiobutanoate - 2.8 1  cabbage, cheesy, eggy, fruit, garlic, metallic, musty, sulfurous, tomato
3-methyl-3-mercapto butyl methyl ether - 2.7 1  catty, blackcurrant
methyl 3-mercaptopropionate - 2.2 1  
2-methyl-3-tetrahydrofuranthiol - 1.9 1  roasted, beefy, chicken, meaty, sulfurous, alliaceous
diallyl sulfide - (agonist) 2  sulfurous, onion, garlic, horseradish, metallic, pungent
delta-damascone - 0 4  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
ethanol - 0 3  alcoholic, ethereal, fruity
Iso-E-Super - 0 4  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
isobutyl alcohol - 0 3  ethereal, winey
isopropyl alcohol - 0 3  alcoholic, ethereal, waxy
3-methyl-2-butanol - 0 3  alcoholic, cheesy, cider, cocoa, fusel, musty, vegetable
propanol - 0 3  alcoholic, fermented, fusel, musty, tequila, yeasty, sweet, fruity, apple, pear
sec-butyl alcohol - 0 3  sweet, apricot
tert-butyl alcohol - 0 3  camphorous
beta-damascenone - 0 4 Y 4natural, sweet, fruity, rose, plum, grape, raspberry, sugar, woody, earthy, green, floral
alpha-damascone - 0 4 Y 4floral, rose, apple, fruity, black_currant, sweet, green, berry
beta-damascone - 0 4 Y 4berry, currant, floral, fruity, honey, plum, rose, tobacco
alpha-ionone - 0 4 Y 4sweet, woody, floral, violet, orris, tropical, fruity
beta-ionone - 0 4 Y 4beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
alpha-isomethyl ionone - 0 4 Y 4orris, woody, floral, dried, fruit, violet, jammy, powdery, tea

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

3.) Shengju Li, Lucky Ahmed, Ruina Zhang, Yi Pan, Hiroaki Matsunami, Jessica L. Burger, Eric Block, Victor S. Batista, and Hanyi Zhuang Smelling Sulfur: Copper and Silver Regulate the Response of Human Odorant Receptor OR2T11 to Low-Molecular-Weight Thiols Journal of the American Chemical Society 2016 138 (40), 13281-13288 DOI: 10.1021/jacs.6b06983

4.) Antagonistic interactions between odorants alter human odor perception Yosuke Fukutani, Masashi Abe, Haruka Saito, Ryo Eguchi, Toshiaki Tazawa, Claire A. de March, Masafumi Yohda, Hiroaki Matsunami bioRxiv 2022.08.02.502184; doi: https://doi.org/10.1101/2022.08.02.502184
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