Names:
cyclohexanone
SMILES:
C1CCC(=O)CC1
Aroma Description:
acetone, minty1
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR2Y1 | 73 | -3.14 7 | - | ||
| OR2F1 | 100 | -7.97 2 | 0.0298 2 | carnation, clove, lavender, sulfurous, rose, malty | |
| OR2J2 | 92 | -5 6 | - | sweet, peach, coconut, tart, carnation, hay, fatty, orange, cinnamon, creamy | |
| OR52D1 | 100 | - | 3.1472 3 | dairy, cheesy, anise, creamy, peach, sweet, fatty, milky, orange, lactonic | |
| OR1G1 | 61 | - | 0.6091 3 | Y | waxy, sweet, citrus, tart, fresh, orange, aldehydic, fatty, rose, floral |
| OR5AN1 | 100 | - | 0.0004 5 | musk, animal | |
| OR10J5 | 84 | - | 0 4 | ||
| OR1A1 | 73 | - | 0 4, 0 5 | ||
| OR2C1 | 100 | - | 0 4 | ||
| OR2W1 | 53 | - | 0 4 | ||
| OR51E1 | 100 | - | 0 4 | ||
| OR51L1 | 88 | - | 0 4 | ||
| OR5P3 | 100 | - | 0 4 | ||
| OR2J3 | 100 | - | 0 5 |
SMILES:
C1CCC(=O)CC1
Aroma Description:
acetone, minty
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
4.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
5.) Ligand Specificity and Evolution of Mammalian Musk Odor Receptors: Effect of Single Receptor Deletion on Odor Detection Narumi Sato-Akuhara, Nao Horio, Aya Kato-Namba, Keiichi Yoshikawa, Yoshihito Niimura, Sayoko Ihara, Mika Shirasu, Kazushige Touhara Journal of Neuroscience 20 April 2016, 36 (16) 4482-4491; DOI: 10.1523/JNEUROSCI.3259-15.2016
6.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
7.) Huiwen Ren, Ruijing Zhang, Haibo Zhang, Che Bian. Ecnomotopic olfactory receptors in metabolic regulation. Biomedicine & Pharmacotherapy 179 (2024) 117403