OR4D2

Olfactory Receptor family 4 subfamily D member 2.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
METGNLTWVS DFVFLGLSQT RELQRFLFLM FLFVYITTVM GNILIIITVT SDSQLHTPMY FLLRNLAVLD LCFSSVTAPK MLVDLLSEKK TISYQGCMGQ 

       110        120        130        140        150        160        170        180        190        200 
IFFFHFLGGA MVFFLSVMAF DRLIAISRPL RYVTVMNTQL WVGLVVATWV GGFVHSIVQL ALMLPLPFCG PNILDNFYCD VPQVLRLACT DTSLLEFLKI 

       210        220        230        240        250        260        270        280        290        300 
SNSGLLDVVW FFLLLMSYLF ILVMLRSHPG EARRKAASTC TTHIIVVSMI FVPSIYLYAR PFTPFPMDKL VSIGHTVMTP MLNPMIYTLR NQDMQAAVRR 

       310 
LGRHRLV

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


V L K D       P   L S T D     M L   S I T K      L L  L E R T  
 G I S   T F P R   F E L   A L Q V   G Q Y    D V L    F R Q   
M V T H   A Y L   S I K L   I S H   Q G M C  M K P A  M L F L  
 M P T   Y I S P   G S N   V F G G   F F I    T V S    F L F   
M P N L   V F I   V D L L   V W T   L F H F  S F C L  T I Y V  
 T Y I   M S V V   F W V   A V V L   A G G    D L V    M V T   
          I I H   L L L F   G V W   F F V M  A L N R  L I N G  
         T T C T   Y S M   L Q T N   V S L    L L F    I I I   
          S A A   L I F L           D F A M  Y M P T  S T V T  
         K R R A   L M V             I L R                 D   
                      S R           R S I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB

Odorant	EC₅₀	Adjusted Top	Antagonist?	Aroma Notes
eugenyl acetate	-4 ¹	(agonist) ¹		carnation, clove, floral, fresh, malty, spicy, sweet, woody

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR4D2	100	96%	F	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	K	N	S	L	D	F	S	Y	P	S	I	H	T
OR4D9	91	100%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	N	V	S	F	C	Y	P	S	V	F	T
OR4D11	91	34%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	F	T
OR4D5	91	80%	Y	L	F	H	G	G	I	F	G	H	S	Q	Y	D	V	P	M	N	N	V	T	F	C	Y	P	S	V	Y	T
OR4D1	89	100%	Y	I	F	H	G	G	V	F	G	H	S	Q	Y	D	V	P	M	N	S	L	V	F	C	Y	P	S	I	Y	T
OR4M1	89		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	I	T	M	S	S	I	S	F	S	Y	P	S	V	H	T
OR4Q3	89	92%	L	I	L	H	G	A	M	F	G	H	S	Q	Y	D	V	P	V	N	S	L	S	F	C	Y	F	S	L	Y	T
OR4N2	88	73%	Y	L	L	H	G	G	G	L	G	H	S	Q	F	D	V	P	M	N	S	M	T	F	G	Y	P	S	L	H	T
OR4N5	88	96%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	L	S	F	A	Y	F	S	L	H	T
OR4Q2	88		Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	V	P	M	N	S	I	S	F	C	Y	F	S	V	Y	N
OR4D10	88	96%	F	M	F	H	G	G	V	F	G	H	S	Q	Y	D	V	H	M	N	N	L	T	F	C	Y	P	S	V	F	T
OR4K14	88	80%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	M	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4D6	87	65%	F	I	F	H	G	G	I	F	G	H	S	Q	Y	Y	V	L	M	N	N	V	T	F	C	Y	P	S	I	N	T
OR4K13	87	96%	L	M	M	H	G	G	M	M	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	S	V	Y	T
OR4E2	87	96%	H	L	L	H	A	C	I	F	G	H	S	Q	F	D	V	P	I	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4M2	85	92%	Y	L	L	H	G	A	M	F	G	H	S	Q	F	D	I	T	M	S	S	I	S	F	S	Y	P	S	V	N	T
OR4F4	85	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F5	85	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4F17	85	92%	L	I	L	H	G	G	M	V	G	H	S	Q	Y	D	L	P	V	N	S	L	T	F	C	Y	P	A	V	Y	S
OR4N4	85	34%	Y	L	L	H	G	G	G	L	G	H	S	Q	F	D	V	R	M	N	S	M	T	F	A	Y	P	S	L	H	T
OR4K1	85		Q	I	L	H	V	G	M	M	G	H	S	H	F	D	L	P	T	N	S	I	S	F	C	Y	P	S	V	Y	T
OR4K17	85	84%	L	I	L	H	G	G	M	V	G	H	S	Q	F	D	L	P	I	N	S	I	S	F	C	Y	P	A	V	Y	T
OR4A47	82		Y	L	E	H	G	G	V	F	G	H	S	Q	F	D	M	Y	V	N	G	A	C	F	C	Y	P	S	V	Y	T
OR4L1	82	11%	L	M	M	H	G	G	M	T	G	H	S	Q	F	D	L	P	V	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4K2	82	100%	L	I	L	H	T	G	I	I	G	H	S	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4A5	81	15%	Y	L	D	H	G	G	V	F	G	H	S	Q	S	D	M	H	V	N	S	I	C	F	C	Y	P	T	V	Y	T
OR4K3	81		L	M	L	H	G	G	I	V	G	H	A	Q	F	D	L	P	M	T	S	I	A	F	C	Y	P	S	V	Y	T
OR4A16	81		Y	L	E	H	G	G	V	F	G	H	S	Q	V	D	M	Y	V	N	G	I	C	F	C	Y	P	T	V	Y	S
OR4K15	81	42%	V	I	V	H	T	G	M	V	G	H	T	Q	F	D	L	P	I	D	S	L	S	F	C	Y	P	A	V	Y	T
OR4B1	80	69%	Y	I	F	H	G	V	I	L	G	H	S	Q	F	D	L	Q	V	N	S	F	S	F	A	Y	P	A	V	Y	T

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