☰

Olfactory Receptor family 4 subfamily E member 2.

Estimated Expression: 96% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDSLNQTRVT EFVFLGLTDN RVLEMLFFMA FSAIYMLTLS GNILIIIATV FTPSLHTPMY FFLSNLSFID ICHSSVTVPK MLEGLLLERK TISFDNCITQ 

       110        120        130        140        150        160        170        180        190        200 
LFFLHLFACA EIFLLIIVAY DRYVAICTPL HYPNVMNMRV CIQLVFALWL GGTVHSLGQT FLTIRLPYCG PNIIDSYFCD VPLVIKLACT DTYLTGILIV 

       210        220        230        240        250        260        270        280        290        300 
TNSGTISLSC FLAVVTSYMV ILVSLRKHSA EGRQKALSTC SAHFMVVALF FGPCIFIYTR PDTSFSIDKV VSVFYTVVTP LLNPFIYTLR NEEVKSAMKQ 

       310        320 
LRQRQVFFTK SYT

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


V V K D       S   L Y T D     T L   S I T K      L L  L V R N  
 F V S   T D P R   I G T   F T Q G   N D F    G E L    L M E   
V V T Y   T Y I   T V I L   L S H   Q T I C  M K P V  A M F F  
 L P T   F I C P   G S N   V T G G   F F L    T V S    A S F   
F P N L   G F F   L S I T   L W L   F L H L  S H C I  L M Y I  
 T Y I   L A V V   F C S   A F V L   A C A    D I F    S L T   
          M F H   V V A L   Q I C   L F I E  S L N S  L I N G  
         A S C T   Y S T   V R M N   I I L    L F F    I I I   
          S L A   L I V M           D Y A V  Y M P T  F V T A  
         K Q R G   L S V             V Y R                 T   
                      K R           T C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
n-amyl acetate -3 1 (agonist) 1  banana, fruity, solvent, sweet, apple, ethereal, pear
geraniol - 1.9231 2  citrus, floral, fruity, rose, sweet, waxy
hydrocinnamaldehyde - 1.9231 2  fresh, cortex, green, leafy, foliage, balsamic, storax, aldehydic, floral, melon
2,4,6-trichloroanisole - 1.9231 2  cork_taint

1.) J.D. Mainland, A. Keller, Y.R. Li, T. Zhou, C. Trimmer, L.L. Snyder, A.H. Moberly, K.A. Adipietro, W.L.L. Liu, H. Zhuang et al, The missense of smell: functional variability in the human odorant receptor repertoire, Nat. Neurosci. 17 (2014) 114-120

2.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR4E2100 96%H L L H A C I F G H S Q F D V P I N S I S F C Y P S V Y T
OR4Q295Y L L H G A M F G H S Q F D V P M N S I S F C Y F S V Y N
OR4D594 80%Y L F H G G I F G H S Q Y D V P M N N V T F C Y P S V Y T
OR4D993 100%F M F H G G V F G H S Q Y D V P M N N V S F C Y P S V F T
OR4D1193 34%F I F H G G I F G H S Q Y D V P M N N V T F C Y P S V F T
OR4Q392 92%L I L H G A M F G H S Q Y D V P V N S L S F C Y F S L Y T
OR4K1492 80%L I L H G G M V G H S Q F D L P M D S L S F C Y P S V Y T
OR4K1391 96%L M M H G G M M G H S Q F D L P V D S L S F C Y P S V Y T
OR4N591 96%Y L L H G A M F G H S Q F D V P M N S L S F A Y F S L H T
OR4N291 73%Y L L H G G G L G H S Q F D V P M N S M T F G Y P S L H T
OR4D191 100%Y I F H G G V F G H S Q Y D V P M N S L V F C Y P S I Y T
OR4D690 65%F I F H G G I F G H S Q Y Y V L M N N V T F C Y P S I N T
OR4D1090 96%F M F H G G V F G H S Q Y D V H M N N L T F C Y P S V F T
OR4K1789 84%L I L H G G M V G H S Q F D L P I N S I S F C Y P A V Y T
OR4M189Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V H T
OR4M288 92%Y L L H G A M F G H S Q F D I T M S S I S F S Y P S V N T
OR4F488 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F588 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4F1788 92%L I L H G G M V G H S Q Y D L P V N S L T F C Y P A V Y S
OR4N488 34%Y L L H G G G L G H S Q F D V R M N S M T F A Y P S L H T
OR4D287 96%F I F H G G V F G H S Q Y D V P K N S L D F S Y P S I H T
OR4A4786Y L E H G G V F G H S Q F D M Y V N G A C F C Y P S V Y T
OR4K186Q I L H V G M M G H S H F D L P T N S I S F C Y P S V Y T
OR4K286 100%L I L H T G I I G H S Q F D L P M T S I A F C Y P S V Y T
OR4L186 11%L M M H G G M T G H S Q F D L P V D S L S F C Y P A V Y T
OR4K385L M L H G G I V G H A Q F D L P M T S I A F C Y P S V Y T
OR4K1585 42%V I V H T G M V G H T Q F D L P I D S L S F C Y P A V Y T
OR4A1685Y L E H G G V F G H S Q V D M Y V N G I C F C Y P T V Y S
OR4C585S L E H G G I I G H A Q I D L F V N S M C F C Y P S V Y T
OR4B184 69%Y I F H G V I L G H S Q F D L Q V N S F S F A Y P A V Y T
OR4F684F I I H G G M V G H S Q F D L P V N S I S F L Y P A I D A
OR4S284 57%Y L V H G C I F G H S Q F D V H V N S I A F C Y D A V Y T
OR4C384 34%Y L A H G G I I G H S Q A D L Y V N S I C F C Y P A L Y G
OR4A583 15%Y L D H G G V F G H S Q S D M H V N S I C F C Y P T V Y T
OR4X283 53%Y L L H G G I F G H S Q F D L V I N G L S F C S S A V Y T
OR4A1583 15%Y L D H A G V I G H S Q L D L Y M N G I C F C Y P T V L T
OR4P482 57%Y L T H G G I F G H S Q F D V Y V N S I A F A Y V A L Y T
OR4X182 23%Y M L H G G A F G H S Q F D V H I N G I S F C Y C A V Y T
OR4C1182 69%F V L H G C I F S H S Q C D L Q L N S I C F C Y P A V Y T
OR4K582 61%Q I I H T G M V S H T Q F D L P I N S L S F C Y P A I Y T
OR10G482 88%F L F H G S C F G H S Q F D A P I D I V A F C Y G A I Y T
OR10G781 80%F L F H G S C F G H S Q F D A P I N I V A F G Y G A V Y T
OR4C1581 69%F L E H A G V I G H S Q M D L Y V N S I C F C Y P A I Y I
OR10G981 46%F L F H G S C F G H S Q L D A P I D I V A F C Y G A I Y T
OR4F1580 92%F I S H G G M V G H S Q Y D L P V N S I S F L Y P A I D A
×
 
 

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