Olfactory Receptor family 52 subfamily I member 2.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL QSSHLWLAIS LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD 110 120 130 140 150 160 170 180 190 200 IVMASSVVPK MVSIFCSGDS SISFSACFTQ MFFVHLATAV ETGLLLTMAF DRYVAICKPL HYKRILTPQV MLGMSMAITI RAIIAITPLS WMVSHLPFCG 210 220 230 240 250 260 270 280 290 300 SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD VAFIAASYIL ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP 310 320 330 340 350 LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 H L P V G P V P D V M S I S S S C S S Q L V Q T L W A A L S S W S L P A S F F I S W L H D A L L Y I S I L S Y T I A Q T F C V M K P S I A L V Y L A M G P S S G I I A R F F M V V S A S L A P I I L Y Y G V M L I T I A L H V S A M V I I Y M N L T L A M V V D S A M S M V A T I D V L L A Y I I P G V H A I F A G L M L G T E A A L V I T N G M G S G C T Y S A V Q P T T L L C L F T V I S L A L I L I D F A M C Y M P M W I A K L Q A V A K V Y R D L G F C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| benzyl salicylate | -5.03 1 | 10 1 | balsamic, clean, herbal, oily, sweet | |
| (Z)-3-hexenyl salicylate | -4.87 1 | - | floral, green, metallic, herbal, balsamic | |
| (Z)-4-hepten-2-yl salicylate | -4.61 1 | - | floral, green, lily, muguet | |
| hexyl salicylate | -4.38 1 | - | fresh, herbal, orchid, green | |
| cyclohexyl salicylate | -4.13 1 | - | floral, balsamic, sweet, green | |
| delta-decalactone | - | 5 2 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| decanal | -2.66 3 | 0.2141 3 | sweet, aldehydic, waxy, orange_peel, citrus, floral | |
| butyric acid | - | 0.4167 2 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| diacetyl | - | 0 2 | buttery, caramellic, creamy, pungent, sweet | |
| (Z)-3-hexenyl benzoate | - | 0 1 | fresh, green, leafy, floral, orchid, balsamic, fatty, sweet, oily, spicy, fruity | |
| salicylic acid | - | 0 1 | aromatic, aspirin, phenolic |
1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
2.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR52I2 | 100 | 100% | M | M | V | H | T | A | T | G | A | A | I | L | Y | E | H | I | S | G | S | M | V | Y | G | I | W | A | D | Y | V |
| OR52I1 | 97 | 100% | M | M | V | H | T | A | T | G | A | F | M | L | Y | K | H | I | S | G | S | M | V | Y | G | I | W | A | D | Y | V |
| OR52N1 | 84 | 92% | M | M | V | H | T | G | S | G | G | L | V | S | Y | D | H | M | G | V | A | I | G | Y | A | F | H | A | N | Y | L |
| OR52E6 | 84 | 88% | L | M | I | H | T | V | S | I | S | M | V | L | Y | E | H | M | F | G | S | L | L | S | A | F | C | A | N | Y | V |
| OR52E1 | 83 | L | M | I | H | T | G | S | A | P | F | V | F | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V | |
| OR52K2 | 83 | 80% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | N | Y | L |
| OR52E2 | 81 | 42% | L | M | I | H | T | L | S | A | A | F | V | S | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V |
| OR52N2 | 81 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52L1 | 81 | 96% | L | M | I | H | S | S | S | G | G | L | L | F | Y | E | H | M | G | M | A | V | I | Y | G | F | R | A | T | Y | L |
| OR52N5 | 81 | 92% | T | M | V | H | T | G | S | G | G | L | M | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52N4 | 80 | 100% | M | M | T | H | T | G | S | G | G | L | I | F | Y | D | H | M | G | V | A | I | W | Y | A | F | R | A | N | Y | L |
| OR52K1 | 80 | 92% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | I | Y | L |
| OR52A1 | 80 | 88% | L | M | I | H | Q | G | S | G | A | L | V | C | Y | E | H | M | G | V | A | V | A | Y | A | F | R | S | S | Y | L |
| OR52R1 | 80 | 73% | L | V | I | H | S | S | S | G | G | W | V | F | Y | E | H | M | G | V | A | V | A | Y | A | F | R | A | N | Y | L |