aldehyde C-10, decanal

SMILES:
CCCCCCCCCC=O

Aroma Description:
sweet, aldehydic, waxy, orange_peel, citrus, floral1

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
VN1R3 ? - 10 7  orange_peel, peely, aldehydic
OR56A4 100 -3.41 2, -1.84 4, -4.41 10 3.1751 2, 2.6667 4, (agonist) 10  cloth, laundered, cheesy, waxy, fatty, orange_peel, creamy, dairy, coconut
VN1R5 ? - 8 7  tart, orange_peel, aldehydic, spearmint, caraway, waxy, peely, citrus, blueberry, rose
OR1A2 19 - 5.5 11  citrus, waxy, aldehydic, orange, fresh, orange_peel, tart, rose, sweet, floral
OR4N5 96 -2.84 2 0.7145 2  (insufficient data)
OR1G1 61 - 3.1472 3  sweet, waxy, citrus, fresh, tart, orange, aldehydic, floral, rose, fatty
OR52D1 100 - 2.9949 3  dairy, cheesy, anise, milky, creamy, sour, sharp, peach, lactonic, rancid
OR52I2 100 -2.66 2 0.2141 2  dairy, milky, balsamic, lactonic, oily, peach, creamy, coconut, herbal, clean
OR1A1 73 - -1.6 4, 0 6, 4 11  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
VN1R1 ? - 0.8 7, 0.3333 8  lemon, lactonic, natural, grapefruit, sweet, jasmine, spearmint, tropical, oily, sharp
OR7D4 96 - 0.1 5  animal, citrus, orange, peely, tart, aldehydic, blueberry
OR10G3 96 - 0.0167 4  vanilla, carnation
OR10J5 84 - 0 4, 0 6   
OR11A1 100 - 0 4   
OR1C1 100 - 0 4   
OR2A25 100 - 0 4   
OR2B11 100 - 0 4   
OR2J2 92 - 0 4, 0 6   
OR2J3 100 - 0 4   
OR2W1 53 - 0 4, 0 6   
OR51E1 100 - 0 4, 0 6   
OR51L1 88 - 0 4, 0 6   
OR5K1 100 - 0 4   
OR8K3 92 - 0 4   
OR2C1 100 - 0 6   
OR5A1 100 - 0 9   
OR5AN1 100 - 0 9   
OR8D1 96 - -0.04 4   
OR10G7 80 - -0.0667 4   
OR5P3 100 - -2.6667 4, 0 6   
 

aldehyde C-10, decanal

SMILES:
CCCCCCCCCC=O

Aroma Description:
sweet, aldehydic, waxy, orange_peel, citrus, floral

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

5.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

7.) Krautwurst D. Human olfactory receptor families and their odorants. Chem Biodivers. 2008 Jun;5(6):842-52. doi: 10.1002/cbdv.200890099. PMID: 18618407.

8.) I. Wallrabenstein, J. Gerber, S. Rasche, I. Croy, S. Kurtenbach, T. Hummel, H. Hatt, The smelling of Hedione results in sex-differentiated human brain activity, NeuroImage, Volume 113, 2015, Pages 365-373, ISSN 1053-8119

9.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D. Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2. J Struct Biol. 2007 Sep;159(3):400-12. doi: 10.1016/j.jsb.2007.04.013. Epub 2007 May 25. PMID: 17601748.

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