SMILES:
CC(C)CC(=O)[O-]
Aroma Description:
cheesy, sour, sweaty, tropical1
| Receptor | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|
| OR11H6 | -3.81 2, -3.52 12 | 0.0679 2, 10 8 | orangeflower, neroli, naphthyl | |
| OR51E1 | -3.68 2, -1.95 4, -2.82 5, -4.82 6, -4.82 12, -4.8 13, -4.82 14 | 5.6998 2, 10 4, 3.3871 6, 9.27 13, 10 14 | cheesy, sweaty, sour, acidic, rancid | |
| OR11H4 | -3.87 2, -3.52 12 | 0.0413 2, 9.2233 8 | honey, cinnamyl, bready, hyacinth, cinnamon | |
| OR51I2 | -4.4 14, -4.17 15 | 9.0909 14, 7.9 15 | sour, cheesy, sweaty, acidic | |
| OR11H7 | -5 8 | 4.5631 8 | (insufficient data) | |
| OR51E2 | -4.19 2 | 0.1444 2 | sour, vinegar, radish, sharp, cabbage, orris | |
| OR1E1 | -4.14 2 | 0.1063 2 | (insufficient data) | |
| OR12D2 | - | 1.7476 8, 1.9231 11 | vinegar, sour | |
| OR8U8 | -3.09 2 | 0.0609 2 | (insufficient data) | |
| OR52D1 | - | 2.8426 3 | anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple | |
| OR4Q2 | - | 2.7184 8 | (insufficient data) | |
| OR8A1 | - | 2.4272 8 | (insufficient data) | |
| OR52E4 | - | 2.1359 8 | dairy, creamy, lactonic, milky, cheesy, sweaty, sharp, peach, sour, buttery | |
| OR7D4 | - | 0.2 7 | animal | |
| OR1G1 | - | 0.0508 3 | waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise | |
| OR5A1 | - | 0 9 | ||
| OR5A2 | - | 0 9 | ||
| OR5AN1 | - | 0 9 | ||
| OR5I1 | - | 0 11 | ||
| OR2W3 | - | -0.4651 10 |
SMILES:
CC(C)CC(=O)[O-]
Aroma Description:
cheesy, sour, sweaty, tropical
| Receptor | Docking Score | Correlated Perceptual Qualities |
|---|
1.) The Good Scents Company
2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002
4.) Pierre Chatelain, Alex Veithen, Francoise Wilkin, and Magali Philippeau Deorphanization and Characterization of Human Olfactory Receptors in Heterologous Cells Chem Biodivers. 2014 Nov;11(11):1764-81. doi: 10.1002/cbdv.201400083. PMID: 25408322.
5.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180
6.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037
7.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
8.) I. Menashe, T. Abaffy, Y. Hasin, S. Goshen, V. Yahalom, C.W. Luetje, D. Lancet, Genetic Elucidation of Human Hyperosmia to Isovaleric Acid, PLoS Biol. 5 (2007) e284.
9.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
10.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.
11.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).
12.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
13.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.
14.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2
15.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047