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Olfactory Receptor family 51 subfamily E member 2.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSSCNFTHAT FVLIGIPGLE KAHFWVGFPL LSMYVVAMFG NCIVVFIVRT ERSLHAPMYL FLCMLAAIDL ALSTSTMPKI LALFWFDSRE ISFEACLTQM 

       110        120        130        140        150        160        170        180        190        200 
FFIHALSAIE STILLAMAFD RYVAICHPLR HAAVLNNTVT AQIGIVAVVR GSLFFFPLPL LIKRLAFCHS NVLSHSYCVH QDVMKLAYAD TLPNVVYGLT 

       210        220        230        240        250        260        270        280        290        300 
AILLVMGVDV MFISLSYFLI IRTVLQLPSK SERAKAFGTC VSHIGVVLAF YVPLIGLSVV HRFGNSLHPI VRVVMGDIYL LLPPVINPII YGAKTKQIRT 

       310        320 
RVLAMFKISC DKDLQAVGGK

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

K E L G   L A L   A E F S       L   P L T D       V   V I P H  
 F H A   I K P M   T L C   L P L P   V V N   V S L G   V V R   
F G V W   T S T   F F M Q   F F F   T L G Y   I L P   I D G M  
 L L P   S L A L   A H I   L S G R   L I A   V Y F A   L L Y   
V Y M S   D I A   I A S L   V V A   G M V L   L V V   V P P L  
 M A V   A L M C   T S E   V I G I   V D V   G I H S   P N I   
C N G F   L F L   A L L I   Q A T   S I F M   V C T   G Y I I  
 V V I   Y M P A   F A M   V T N N   Y S L   G F A K     K A   
R V I F           V Y R D           I I L F   A R E            
                   C I A             V T R   S K S P           
                        H               Q L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
hydroxypyruvic acid -6.38 1 11 1  sour, radish, cabbage
alpha-ionone -5.5 2 10 2  sweet, woody, floral, violet, orris, tropical, fruity
beta-ionone -7.5 2 5.9375 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
propionic acid -3.96 3 10 4  acidic, cheesy, pungent, vinegar
acetic acid -3.7 4 6.9565 4  sharp, pungent, sour, vinegar
butyric acid -4.52 4 2.6087 4  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
formic acid -4.7 4 0.8696 4  pungent, vinegar
isovaleric acid -4.19 5 0.1444 5  cheesy, sour, sweaty, tropical
delta-decalactone - 2.0833 6  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
valeric acid - 0.4 7  acidic, cheesy, fruity, milky, sharp, sour, tobacco
capric acid - 0 7  citrus, fatty, rancid, sour
caproic acid - 0 7  cheesy, fatty, sour, sweaty
caprylic acid - 0 7  cheesy, fatty, oily, rancid, vegetable, waxy
diacetyl - 0 6  buttery, caramellic, creamy, pungent, sweet
oenanthic acid - 0 7  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 7  cheesy, dairy, dirty, waxy

1.) Abaffy, T.; Bain, J.R.; Muehlbauer, M.J.; Spasojevic, I.; Lodha, S.; Bruguera, E.; O’Neal, S.K.; Kim, S.Y.; Matsunami, H. A Testosterone Metabolite 19-Hydroxyandrostenedione Induces Neuroendocrine Trans-Differentiation of Prostate Cancer Cells via an Ectopic Olfactory Receptor. Front. Oncol. 2018, 8, 162

2.) Sanz G., Leray I., Grébert D., Antoine S., Acquistapace A., Muscat A., Boukadiri A., Mir L. M. Structurally related odorant ligands of the olfactory receptor OR51E2 differentially promote metastasis emergence and tumor growth. Oncotarget. 2017; 8: 4330-4341.

3.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

4.) Aisenberg, W., Huang, J., Zhu, W. et al. Defining an olfactory receptor function in airway smooth muscle cells. Sci Rep 6, 38231 (2016). https://doi.org/10.1038/srep38231

5.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

6.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

7.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951
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