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Olfactory Receptor family 2 subfamily W member 3.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGTNGSTQT HFILLGFSDR PHLERILFVV ILIAYLLTLV GNTTIILVSR LDPHLHTPMY FFLAHLSFLD LSFTTSSIPQ LLYNLNGCDK TISYMGCAIQ 

       110        120        130        140        150        160        170        180        190        200 
LFLFLGLGGV ECLLLAVMAY DRCVAICKPL HYMVIMNPRL CRGLVSVTWG CGVANSLAMS PVTLRLPRCG HHEVDHFLRE MPALIRMACV STVAIEGTVF 

       210        220        230        240        250        260        270        280        290        300 
VLAVGVVLSP LVFILLSYSY IVRAVLQIRS ASGRQKAFGT CGSHLTVVSL FYGNIIYMYM QPGASSSQDQ GMFLMLFYNI VTPLLNPLIY TLRNREVKGA 

       310        320 
LGRLLLGKRE LGKE

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L H P R   N Y L   G M Y S     T V   A V T S       Q   Q D Q S  
 I R E   L Q P I   I A C   P S M A   G E I   M Y M Y   F M G   
V V F L   S S T   L F L Q   L S N   V F V T   I I N   F L M L  
 I L I   T F S L   G L F   A V G C   V A L   G Y F L   I N Y   
L L Y A   D L F   V G G L   G W T   L V V G   S V V   L P T V  
 V L T   S L H A   L C E   V S V L   L P S   T L H S   P N L   
T T N G   L F F   V A L L   G R C   L I F V   G C T   T Y I L  
 L I I   Y M P T   Y A M   L R P N   Y S L   G F A K     R L   
  R S V           V C R D           V I Y S   Q R G            
                   C I A             V A R   S A S R           
                        K               Q L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
citralva - 10 1  aldehydic, citrus, lemon, metallic
geraniol - 8.1395 1  citrus, floral, fruity, rose, sweet, waxy
ethyl vanillin - 7.907 1  sweet, creamy, vanilla, caramellic
eugenol - 7.2093 1  clove, spicy, sweet, woody
lilial - 6.2791 1  floral, muguet, watery, green, powdery, cumin
beta-ionone - 6.0465 1  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
hedione - 5.814 1  floral, oily, jasmine, green, lactonic, tropical, natural, sweet, fruity, citrus, lemon, grapefruit, woody
nerol -3.2 1 6.0465 1  citrus, floral, fresh, green, lemon, lime, magnolia, natural, neroli, spicy, sweet, waxy
lyral - 4.186 1  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
menthone - 2.7907 1  minty
maltol - 2.3256 1  sweet, caramellic, cotton_candy, jammy, fruity, bread, baked
(S)-(-)-citronellol - 1.8605 1  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
linalool - 0.9302 1  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
allyl phenylacetate - 0 2  honey, fruity, rummy
benzyl alcohol - 0 1  floral, rose, phenolic, balsamic
eucalyptol - 0 1  camphoraceous, eucalyptus, herbal
pyrazine - 0 1  pungent, sweet, corn, roasted, hazelnut, barley
pyrrolidine - 0 1  ammoniacal, animal, eggy, fishy, shellfish, seaweed
tetramethylpyrazine - 0 1  nutty, musty, chocolate, coffee, cocoa, brown, lard, burnt
triethylamine - 0 1  
isovaleric acid - -0.4651 1  cheesy, sour, sweaty, tropical

1.) Huang, J., Lam, H., Koziol-White, C., Limjunyawong, N., Kim, D., Kim, N., ... & An, S. S. (2020). The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR. Proceedings of the National Academy of Sciences, 117(45), 28485-28495.

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
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