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Olfactory Receptor family 5 subfamily A member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC 

       110        120        130        140        150        160        170        180        190        200 
AAQFFFFVGM GLSECLLLTA MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF FCDLPPVLAL SCSDTFLSQV 

       210        220        230        240        250        260        270        280        290        300 
VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI 

       310        320 
KDALWKVLER KKVFS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E P H        F  G V F S       S   L F T D     P R   R G L L  
 L A Q    D T L    A A C   S A Q I   V Q S   L Y V F   V K D   
T V F L  M N P A  F F F Q   L S S   L F N V   L A T   F V S V  
 G L F    V A S    G V F   L F G G   V V V   G F L L   L S Y   
T L Y I  S Y C I  S L G M   V Y A   G G V T   T V V   M P I V  
 A L T    D I F    L C E   G V V M   F S T   M L H S   P N L   
A L N W  S L N S  A T L L   R T C   L L Q L   A C T   S Y I L  
 F I L    L F F    Y A M   L G Q T   Y S I   N C A K       L   
  R I L  Y M P T  A Y R D           V I Y G   W R G            
                   S I A             V A S   E A S P           
                        S               K L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
ambrinol - 10 1  amber, natural, musk, animal
beta-ionone -5.35 2 10 3  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
ysamber - 0.5 1  dry, woody, vetiver, amber, powdery, musk, fruity
acetic acid - 0 1  sharp, pungent, sour, vinegar
acetophenone - 0 1  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
amber butanol - 0 1  woody, amber, ambrette
amber xtreme - 0 1  animal, musk, woody, spicy
amberketal - 0 1  dry, amber, powdery, woody, musk
ambrettolide - 0 1  sweet, soapy, musk, amber, fruity, berry
ambroxide - 0 1  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
benzoic acid - 0 1  balsamic, urine
benzyl propionate - 0 1  sweet, fruity, floral, banana, jasmin, balsamic, apple, jammy
boisambrene - 0 1  woody, cedar, ambergris, dry, dusty, amber
borneol - 0 1  pine, woody, camphoreous, peppery, earthy, minty, herbal, musty
p-t-butyl cyclohexanone - 0 1  woody, minty, patchouli, musk, leathery
calone - 0 1  fresh, watery, clean, melon, green, marine, ozone, phenolic
camphene - 0 1  woody, herbal, fir_needle
camphor - 0 1  camphoraceous
caproic acid - 0 1  cheesy, fatty, sour, sweaty
caprylic acid - 0 1  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 1  herbal, minty, spearmint, sweet
celestolide - 0 1  ambergris, animal, cedar, musk, woody
1,4-cineol - 0 1  cooling, pine, minty, camphoraceous, terpenic, green
civetone - 0 1  clean, musk, dry, animal, sweet
claritone - 0 1  sweet, herbal, clary_sage, sage, bergamot, petitgrain, tropical, citrus
cosmone - 0 1  ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
p-cresyl phenyl acetate - 0 1  animal, rose, honey, narcissus, lily, hyacinth
cyclododecanone - 0 1  
cyclopentadecane - 0 1  
cyclopentadecanol - 0 1  musk
cyclopentadecanone - 0 1  animal, greasy, musk, natural, powdery
beta-damascone - 0 1  berry, currant, floral, fruity, honey, plum, rose, tobacco
gamma-decalactone - 0 1  fresh, oily, waxy, peach, coconut, buttery, sweet
decanal - 0 1  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 1  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
delta-dodecalactone - 0 1  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
1-dodecanol - 0 1  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
omega-dodecanolactam - 0 1  
ethylene brassylate - 0 1  ambrette, floral, musk, powdery, sweet, woody
exaltolide - 0 1  animal, fruity, musk, natural, powdery
fructone - 0 1  apple, fruity, green, plum, sweet, tropical, woody
galaxolide - 0 1  floral, musk, sweet
geraniol - 0 1  citrus, floral, fruity, rose, sweet, waxy
globanone - 0 1  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
habanolide - 0 1  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
helional - 0 1  cyclamen, fresh, green, hay, ozone, watery
helvetolide - 0 1  musk, ambrette, fruity, pear, woody, floral
hexanal - 0 1  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
1-hexanol - 0 1  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
(Z)-3-hexen-1-ol - 0 1  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent
(Z)-3-hexenyl hexanoate - 0 1  fruity, green, waxy, pear, winey, tropical, grassy, pineapple
Iso-E-Super - 0 1  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
isoamyl butyrate - 0 1  fruity, green, apricot, pear, banana
isoborneol - 0 1  balsamic, camphoraceous, herbal, woody
isobornyl acetate - 0 1  balsamic, camphoraceous, herbal, woody, sweet, citrus, soapy, terpenic, pine
isolongifolanone - 0 1  dry, woody, patchouli, cedar, earthy, tobacco, incense
isomenthone - 0 1  minty, cooling, peppermint, sweet
isovaleric acid - 0 1  cheesy, sour, sweaty, tropical
jasmolactone delta - 0 1  oily, fruity, coconut, floral, petal, jasmine, tuberose, peach, apricot
d-limonene - 0 1  citrus, orange, fresh, sweet
melonal - 0 1  fresh, ozone, melon, watermelon, sweet, clean, green
(-)-menthol - 0 1  peppermint, cooling, mentholic, minty, camphoreous, clean
methyl cinnamate - 0 1  balsamic, cherry, strawberry, sweet
methyl nonyl acetaldehyde - 0 1  fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic
6-methyl quinoline - 0 1  leathery, tonka, castoreum, tobacco, civet, fecal
muscenone - 0 1  animal, musk, soapy
muscone - 0 1  musk, animal, powdery
musk ketone - 0 1  dry, fatty, floral, musk, powdery, soapy
musk xylene - 0 1  dry, fatty, musk, soapy, sweet
gamma-nonalactone - 0 1  buttery, coconut, creamy, oily, sweet, waxy
gamma-octalactone - 0 1  sweet, coconut, waxy, creamy, tonka, dairy, fatty
octanal - 0 1  aldehydic, citrus, fatty, green, orange, peel, waxy
1-octanol - 0 1  aldehydic, green, mushroom, orange, rose, waxy
oranger crystals - 0 1  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
orris hexanone - 0 1  woody, dry, orris, earthy, camphoraceous
2-pentadecanone - 0 1  burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone - 0 1  
phenethyl acetate - 0 1  floral, fruity, honey, rose, sweet, tropical
phenylacetic acid - 0 1  sweet, honey, floral, honeysuckle, sour, waxy, civet
piperonyl acetone - 0 1  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
raspberry ketone - 0 1  berry, floral, jammy, raspberry, ripe, seedy, sweet, woody
romandolide - 0 1  musk, ambrette, fruity, berry
santaliff - 0 1  sandalwood, creamy, woody, milky, waxy, greasy, musk
(R)-(+)-sclareolide - 0 1  dry, paper, woody, ambergris, labdanum
styralyl acetate - 0 1  green, leafy, gardenia, rhubarb, musty
sulcatone - 0 1  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
alpha-terpinene - 0 1  woody, terpenic, lemon, herbal, medicinal, citrus
tonalide - 0 1  amber, ambrette, fruity, musk, powdery, sweet
tonka undecanone - 0 1  sweet, spicy, balsamic, tonka, woody, tobacco, green
gamma-undecalactone - 0 1  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
valeric acid - 0 1  acidic, cheesy, fruity, milky, sharp, sour, tobacco
gamma-valerolactone - 0 1  herbal, sweet, warm, tobacco, cocoa, woody
woody cyclohexanone - 0 1  woody, old_wood, amber, tobacco, herbal

1.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

2.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

3.) S.R. Jaeger, J.F. McRae, C.M. Bava, M.K. Beresford, D. Hunter, Y. Jia, S.L. Chheang, D. Jin, M. Peng, J.C. Gamble et al, A Mendelian Trait for Olfactory Sensitivity Affects Odor Experience and Food Selection, Curr. Biol. 23 (2013) 1601-1605.
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