☰

Olfactory Receptor family 52 subfamily A member 5.

Estimated Expression: 92% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MPTFNGSVFM PSAFILIGIP GLESVQCWIG IPFSAMYLIG VIGNSLILVI IKYENSLHIP MYIFLAMLAA TDIALNTCIL PKMLGIFWFH LPEISFDACL 

       110        120        130        140        150        160        170        180        190        200 
FQMWLIHSFQ AIESGILLAM ALDRYVAICI PLRHATIFSQ QFLTHIGLGV TLRAAILIIP SLGLIKCCLK HYRTTVISHS YCEHMAIVKL ATEDIRVNKI 

       210        220        230        240        250        260        270        280        290        300 
YGLFVAFAIL GFDIIFITLS YVQIFITVFQ LPQKEARFKA FNTCIAHICV FLQFYLLAFF SFFTHRFGSH IPPYIHILLS NLYLLVPPFL NPIVYGVKTK 

       310        320 
QIRDHIVKVF FFKKVT

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


I Y P P       G   V R I D     I L   S I E P      F W  V S E L  
 L I H   F R H T   I K N   G L S P   A D F    F I G    W C Q   
L N S L   F F S   F L G Y   I I L   Q F L C  L M K P  P I G I  
 L L Y   F F A L   F A V   I A A R   L W M    L I C    A S F   
F P P V   L Y F   G L I A   L T V   F S H I  T N L A  I L Y M  
 P N L   Q L F V   I D F   G L G I   I A Q    I D T    I V G   
G Y V I   C I H   T I F I   H T L   I G S E  A A L M  L S N G  
     V   A I C T   Y S L   F Q Q S   A L L    A L F    V L I   
          N F A   F I Q V           D L A M  I Y M P  Y K I I  
         K F R A   V T I             V Y R                 E   
                    L Q F             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
4-ethyloctanoic acid -5.74 1 10 1  goaty, lamb, mutton, fatty
4-methyloctanoic acid -5.05 2 -  goat, mutton
caprylic acid -3.94 1 -  cheesy, fatty, oily, rancid, vegetable, waxy
pelargonic acid -3.68 2 -  cheesy, dairy, dirty, waxy
oenanthic acid - (agonist) 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity

1.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR52A5100 92%L M I H Q A S G A L I S Y E H M G V A I L Y A F R L L N L
OR52E291 42%L M I H T L S A A F V S Y E H M G A I L V Y A F R A N Y V
OR52K189 92%L M L H S I S A A L M L Y E H M G V A I V Y V S R A I Y L
OR52N189 92%M M V H T G S G G L V S Y D H M G V A I G Y A F H A N Y L
OR52A188 88%L M I H Q G S G A L V C Y E H M G V A V A Y A F R S S Y L
OR52E188L M I H T G S A P F V F Y E H M G A I L V Y A F R A N Y V
OR52N286 100%L M V H T G S G N L I F Y D H M G V A I G Y A F R A N Y L
OR52P186A M I H C M S T G L M C Y E H M G A A V I Y A F R A N Y L
OR52K286 80%L M L H S I S A A L M L Y E H M G V A I V Y V S R A N Y L
OR52L186 96%L M I H S S S G G L L F Y E H M G M A V I Y G F R A T Y L
OR52N586 92%T M V H T G S G G L M F Y D H M G V A I G Y A F R A N Y L
OR52N485 100%M M T H T G S G G L I F Y D H M G V A I W Y A F R A N Y L
OR52R185 73%L V I H S S S G G W V F Y E H M G V A V A Y A F R A N Y L
OR52A484 46%L M I H Q G S G P L V C Y E R V G G A V G Y A I Q H L Q S
OR52E482 88%L M I H T G T V N L V F Y E H R G V I I I Y A F R A N Y V
OR52E882 84%L M I H T A S I S M V L Y E H M G N I L L F A F R A N Y V
OR52D181 100%L M V H Y A S S S I V F Y E H M G V A A M Y A F R A N Y V
OR52H181 100%L M L H F V S A S I I D Y E H I G V P T V Y A I R A N Y I
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