Olfactory Receptor family 52 subfamily E member 4.
Estimated Expression: 88% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MPSINDTHFY PPFFLLLGIP GLDTLHIWIS FPFCIVYLIA IVGNMTILFV IKTEHSLHQP MFYFLAMLSM IDLGLSTSTI PKMLGIFWFN LQEISFGGCL 110 120 130 140 150 160 170 180 190 200 LQMFFIHMFT GMETVLLVVM AYDRFVAICN PLQYTMILTN KTISILASVV VGRNLVLVTP FVFLILRLPF CGHNIVPHTY CEHRGLAGLA CAPIKINIIY 210 220 230 240 250 260 270 280 290 300 GLMVISYIIV DVILIASSYV LILRAVFRLP SQDVRLKAFN TCGSHVCVML CFYTPAFFSF MTHRFGQNIP HYIHILLANL YVVVPPALNP VIYGVRTKQI 310 320 REQIVKIFVQ KE
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 I Y H P G I K I P I L S I E Q F W L T D L L I H F R H T I I N F V F P G G F F I G W I H L N A L M F S M L G Y T V L Q L L C L M K P P F S I V V Y F F A P S I V V L N R F F M I T S I C F A P P V T Y F V I I Y G V V F M H I T S L G I L Y V P N L C L M V I V D V S A L M G T L D I V I A G Y I V C V H S A I L I S I L V T E M S L M T M N G V S G C T V Y S T K N T V V L A L F F L I N F A R L I L D Y A M Y F M P T K I V K L R V F V A V F R E L R C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| delta-decalactone | - | 2.5 1 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| butyric acid | - | 2.0833 1 | sharp, acetic, cheesy, buttery, fruity, dairy, creamy | |
| isovaleric acid | - | 0 2 | cheesy, sour, sweaty, tropical | |
| diacetyl | - | 0.4167 1 | buttery, caramellic, creamy, pungent, sweet |
1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.
2.) I. Menashe, T. Abaffy, Y. Hasin, S. Goshen, V. Yahalom, C.W. Luetje, D. Lancet, Genetic Elucidation of Human Hyperosmia to Isovaleric Acid, PLoS Biol. 5 (2007) e284.
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR52E4 | 100 | 88% | L | M | I | H | T | G | T | V | N | L | V | F | Y | E | H | R | G | V | I | I | I | Y | A | F | R | A | N | Y | V |
| OR52N2 | 95 | 100% | L | M | V | H | T | G | S | G | N | L | I | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52E1 | 91 | L | M | I | H | T | G | S | A | P | F | V | F | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V | |
| OR52E8 | 90 | 84% | L | M | I | H | T | A | S | I | S | M | V | L | Y | E | H | M | G | N | I | L | L | F | A | F | R | A | N | Y | V |
| OR52D1 | 89 | 100% | L | M | V | H | Y | A | S | S | S | I | V | F | Y | E | H | M | G | V | A | A | M | Y | A | F | R | A | N | Y | V |
| OR52N5 | 88 | 92% | T | M | V | H | T | G | S | G | G | L | M | F | Y | D | H | M | G | V | A | I | G | Y | A | F | R | A | N | Y | L |
| OR52L1 | 87 | 96% | L | M | I | H | S | S | S | G | G | L | L | F | Y | E | H | M | G | M | A | V | I | Y | G | F | R | A | T | Y | L |
| OR52E2 | 87 | 42% | L | M | I | H | T | L | S | A | A | F | V | S | Y | E | H | M | G | A | I | L | V | Y | A | F | R | A | N | Y | V |
| OR52N4 | 87 | 100% | M | M | T | H | T | G | S | G | G | L | I | F | Y | D | H | M | G | V | A | I | W | Y | A | F | R | A | N | Y | L |
| OR52R1 | 87 | 73% | L | V | I | H | S | S | S | G | G | W | V | F | Y | E | H | M | G | V | A | V | A | Y | A | F | R | A | N | Y | L |
| OR52K2 | 86 | 80% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | N | Y | L |
| OR52N1 | 84 | 92% | M | M | V | H | T | G | S | G | G | L | V | S | Y | D | H | M | G | V | A | I | G | Y | A | F | H | A | N | Y | L |
| OR51A2 | 84 | 84% | L | E | I | H | S | V | S | S | S | L | V | F | Y | L | H | Q | G | G | A | L | M | Y | I | A | R | A | N | L | L |
| OR51A4 | 84 | 84% | L | E | I | H | S | V | S | S | S | L | V | F | Y | L | H | Q | G | G | A | L | M | Y | I | A | R | A | N | L | L |
| OR52A1 | 84 | 88% | L | M | I | H | Q | G | S | G | A | L | V | C | Y | E | H | M | G | V | A | V | A | Y | A | F | R | S | S | Y | L |
| OR52E6 | 84 | 88% | L | M | I | H | T | V | S | I | S | M | V | L | Y | E | H | M | F | G | S | L | L | S | A | F | C | A | N | Y | V |
| OR51D1 | 83 | 65% | L | M | I | H | S | A | S | A | G | F | F | L | F | L | H | Q | G | I | I | V | M | Y | L | S | R | A | N | Y | L |
| OR52K1 | 83 | 92% | L | M | L | H | S | I | S | A | A | L | M | L | Y | E | H | M | G | V | A | I | V | Y | V | S | R | A | I | Y | L |
| OR52H1 | 83 | 100% | L | M | L | H | F | V | S | A | S | I | I | D | Y | E | H | I | G | V | P | T | V | Y | A | I | R | A | N | Y | I |
| OR52P1 | 83 | A | M | I | H | C | M | S | T | G | L | M | C | Y | E | H | M | G | A | A | V | I | Y | A | F | R | A | N | Y | L | |
| OR52A5 | 82 | 92% | L | M | I | H | Q | A | S | G | A | L | I | S | Y | E | H | M | G | V | A | I | L | Y | A | F | R | L | L | N | L |
| OR51E1 | 82 | 100% | I | M | I | H | S | G | S | T | G | L | M | L | Y | L | H | Q | G | V | I | A | I | Y | F | S | R | A | N | Y | L |
| OR52B2 | 81 | 100% | L | G | V | H | F | V | S | A | S | I | I | V | Y | E | H | I | G | V | P | M | V | Y | S | L | H | A | N | Y | V |
| OR51F2 | 80 | 84% | L | M | L | H | T | F | S | G | N | V | M | V | Y | Y | H | V | G | A | L | T | T | Y | L | S | R | A | N | F | L |