propanoic acid

SMILES:
CCC(=O)[O-]

Aroma Description:
acidic, cheesy, pungent, vinegar1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51E2 -3 2, -3.96 6, -3.6 7, -3 10 0.4844 2, 9 6, 10 7, 3.4 10  sour, vinegar, radish, sharp, cabbage, orris
OR51E1 -4.97 5 -  cheesy, sweaty, sour, acidic, rancid
OR52D1 - 2.5381 3  anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple
OR12D2 - 1.9231 8  vinegar, sour
OR1G1 - 0.5076 3  waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise
OR10G3 - 0 4   
OR10G7 - 0 4   
OR10J5 - 0 4, 0 6   
OR11A1 - 0 4   
OR1C1 - 0 4   
OR2A25 - 0 4   
OR2B11 - 0 4   
OR2J2 - 0 4, 0 6   
OR2J3 - 0 4   
OR2W1 - 0 4, 0 6   
OR51L1 - 0 4, 0 6   
OR56A4 - 0 4   
OR5K1 - 0 4   
OR5P3 - 0 4, 0 6   
OR8D1 - 0 4   
OR8K3 - 0 4   
OR2C1 - 0 6   
OR5I1 - 0 8   
OR1A1 - -1.2333 4, 0 6   

propanoic acid

SMILES:
CCC(=O)[O-]

Aroma Description:
acidic, cheesy, pungent, vinegar

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

5.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037

6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

7.) Aisenberg, W., Huang, J., Zhu, W. et al. Defining an olfactory receptor function in airway smooth muscle cells. Sci Rep 6, 38231 (2016). https://doi.org/10.1038/srep38231

8.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

9.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

10.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951