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Olfactory Receptor family 8 subfamily D member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MTMENYSMAA QFVLDGLTQQ AELQLPLFLL FLGIYVVTVV GNLGMILLIA VSPLLHTPMY YFLSSLSFVD FCYSSVITPK MLVNFLGKKN TILYSECMVQ 

       110        120        130        140        150        160        170        180        190        200 
LFFFVVFVVA EGYLLTAMAY DRYVAICSPL LYNAIMSSWV CSLLVLAAFF LGFLSALTHT SAMMKLSFCK SHIINHYFCD VLPLLNLSCS NTHLNELLLF 

       210        220        230        240        250        260        270        280        290        300 
IIAGFNTLVP TLAVAVSYAF ILYSILHIRS SEGRSKAFGT CSSHLMAVVI FFGSITFMYF KPPSSNSLDQ EKVSSVFYTT VIPMLNPLIY SLRNKDVKKA 

       310 
LRKVLVGK

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

L E A Q      L F  E S Y L     M A   L H T N  F Y M F  Q D L S  
 P L Q    N V L    V M C   S T H T   L E N    T I S    V K E   
L L F L  M K P T  F F L Q   L A S   I F L L  G F F I  F V S S  
 G L F    I V S    V V F   L F G L   G A I    V V A    T T Y   
V V Y I  S Y C F  A V V F   F F A   L T N F  M L H S  M P I V  
 V V T    D V F    Y G E   A L V L   T P V    S C T    P N L   
G L N G  S L S S  A T L L   L S C   A V A L  G F A K  S Y I L  
 L I M    L F Y    Y A M   V W S S   Y S V    S R G        L   
  A I L  Y M P T  V Y R D           L I F A  E S S R           
                   C I A             I S Y                     
                        S               H L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
sotolone -6.4 1 10 1  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
abhexone -5.5 2 5 2  sweet, fruity, caramellic, maple, fenugreek, brown, sugar, nutty, chicory, praline, butterscotch
(S)-sotolone -4.07 3 -  sweet, milky, acidic, nutty
(R)-sotolone -3.78 3 -  smoky, burnt, herbal, green
oenanthic acid -3.58 4 0.0803 4  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
p-cymene -2.27 4 1.1909 4  fresh, citrus, terpenic, woody, spicy, chemical, lemon, cumin, origanum, cilantro
androstadienone -1.45 4 0.0683 4  animal, musky
allyl phenylacetate - 0 5  honey, fruity, rummy
amyl hexanoate - 0 5  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 5  animal, musky
l-arabinose - 0 5  
benzene - 0 5  
butyl formate - 0 5  fruity, plum, rummy, brandy
butyric acid - 0 5  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 5  bready, caraway, minty, spicy
citral - 0 5  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coumarin - 0 5  coumarinic, hay, sweet, tonka
beta-damascone - 0 5  berry, currant, floral, fruity, honey, plum, rose, tobacco
2,4-DNT - 0 5  
eugenol - 0 5  clove, spicy, sweet, woody
eugenyl acetate - 0 5  carnation, clove, floral, fresh, malty, spicy, sweet, woody
geranyl acetate - 0 5  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
(Z)-3-hexen-1-ol - 0 5  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent
d-limonene - 0 5  citrus, orange, fresh, sweet
linalool - 0 5  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 5  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
methyl eugenol - 0 5  carnation, cinnamon, clove, fresh, spicy, sweet, warm
nonanal - 0 5  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 5  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 5  sulfurous
1-octanol - 0 5  aldehydic, green, mushroom, orange, rose, waxy
pelargonic acid - 0 5  cheesy, dairy, dirty, waxy
propionic acid - 0 5  acidic, cheesy, pungent, vinegar
ethyl vanillin - -0.0167 5  sweet, creamy, vanilla, caramellic
dimethyl disulfide - -0.02 5  sulfurous, vegetable, cabbage, onion, malty, creamy
isobutylamine - -0.0217 5  cheesy, fishy
octyl octanoate - -0.0233 5  coconut, oily, fruity
helional - -0.025 5  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - -0.025 5  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
methyl salicylate - -0.0267 5  minty, wintergreen
terpinyl acetate - -0.0283 5  bergamot, citrus, herbal, lavender, lime
coffee difuran - -0.03 5  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
methyl furfuryl disulfide - -0.03 5  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
propanal - -0.0317 5  alcoholic, cocoa, earthy, nutty, whiskey, winey
quinoline - -0.0317 5  earthy, medicinal, musty, rubbery, tobacco
pentanol - -0.0333 5  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
pyrazine - -0.0333 5  pungent, sweet, corn, roasted, hazelnut, barley
(+)-menthol - -0.0367 5  cooling, mentholic, minty
decanal - -0.04 5  sweet, aldehydic, waxy, orange_peel, citrus, floral
2-ethyl fenchol - -0.0433 5  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
vernolide - -0.1538 1  
jasminaldehyde - -0.1692 1  
habanolide - -0.1769 1  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
ambrettolide - -0.2 1  sweet, soapy, musk, amber, fruity, berry
(R,S)-methyl cedryl ketone - -0.2462 1  woody, vetiver, amber, leathery, musk, cedar
(5E)-3-methylcyclopenta-5-decen-1-one - -0.2538 1  
muscone - -0.2538 1  musk, animal, powdery
bourgeonal - -0.2769 1  fresh, watery, floral, cyclamen, sweet

1.) Aya NAMBA, Naoko Saito, Michiaki Inoue, Tsuyoshi TOYABE (2016) Inhibitor of odor caused by sotolone US9254248B2

2.) HAAG, Franziska, HOFFMANN, Sandra, et KRAUTWURST, Dietmar. Key Food Furanones Furaneol and Sotolone Specifically Activate Distinct Odorant Receptors. Journal of Agricultural and Food Chemistry, 2021, vol. 69, no 37, p. 10999-11005.

3.) Juan Wang, Danqing Wang, Mingquan Huang, Baoguo Sun, Fazheng Ren, Jihong Wu, Jinglin Zhang, Hehe Li, and Xiaotao Sun Decoding Molecular Mechanism Underlying Human Olfactory Receptor OR8D1 Activation by Sotolone Enantiomers Journal of Agricultural and Food Chemistry Article ASAP DOI: 10.1021/acs.jafc.3c09142

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
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