☰

Olfactory Receptor family 51 subfamily L member 1.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MGDWNNSDAV EPIFILRGFP GLEYVHSWLS ILFCLAYLVA FMGNVTILSV IWIESSLHQP MYYFISILAV NDLGMSLSTL PTMLAVLWLD APEIQASACY 

       110        120        130        140        150        160        170        180        190        200 
AQLFFIHTFT FLESSVLLAM AFDRFVAICH PLHYPTILTN SVIGKIGLAC LLRSLGVVLP TPLLLRHYHY CHGNALSHAF CLHQDVLRLS CTDARTNSIY 

       210        220        230        240        250        260        270        280        290        300 
GLCVVIATLG VDSIFILLSY VLILNTVLDI ASREEQLKAL NTCVSHICVV LIFFVPVIGV SMVHRFGKHL SPIVHILMAD IYLLLPPVLN PIVYSVRTKQ 

       310        320 
IRLGILHKFV LRRRF

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

Y E L G   V A L   A S A Q       L   T R A D       V   V I P S  
 S H V   M T P L   A Y C   L P T P   I S N   M S V G   L I H   
I S L W   T S L   F F L Q   L V V   C L G Y   I V P   I D A M  
 C F L   S M G L   T H I   G L S R   I V V   V F F I   L L Y   
L Y A L   D N V   L F T F   L L C   G L T A   L V V   V P P L  
 F A V   A L I S   S S E   A L G I   S D V   C I H S   P N L   
V N G M   I F Y   A L L V   K G I   L I F I   V C T   S Y V I  
 L I T   Y M P Q   F A M   V S N T   Y S L   N L A K     R V   
W I V S           V F R D           L I L V   L Q E            
                   C I A             V T N   E R S A           
                        H               D L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
allyl phenylacetate -7.92 1 9 2  honey, fruity, rummy
caproic acid -5 3 9.5 2  cheesy, fatty, sour, sweaty
diacetyl - 1.6667 4  buttery, caramellic, creamy, pungent, sweet
acetophenone - 0 2  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate - 0 2  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allylbenzene - 0 2  
amyl hexanoate - 0 5  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 5  animal, musky
l-arabinose - 0 5  
benzene - 0 5  
benzophenone - 0 2  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 2  sweet, floral, fruity, jasmine, fresh
butyl butyryl lactate - 0 2  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
butyl formate - 0 5  fruity, plum, rummy, brandy
butyric acid - 0 5  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(-)-camphor - 0 2  
camphor - 0 2  camphoraceous
capric acid - 0 2  citrus, fatty, rancid, sour
gamma-caprolactone - 0 2  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
caprylic acid - 0 2  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 2  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 5  bready, caraway, minty, spicy
4-chromanone - 0 2  
citral - 0 5  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
(S)-(-)-citronellol - 0 2  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran - 0 5  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 2  
coumarin - 0 5  coumarinic, hay, sweet, tonka
cyclohexanone - 0 2  acetone, minty
beta-damascone - 0 5  berry, currant, floral, fruity, honey, plum, rose, tobacco
delta-decalactone - 0 4  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
decanal - 0 5  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 2  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
(+)-dihydrocarvone - 0 2  herbal, minty, mentholic
dihydrojasmone - 0 2  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
dimethyl disulfide - 0 5  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 5  
2-ethyl fenchol - 0 5  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate - 0 2  alcoholic, ethereal, fruity, fusel, rummy, sweet
ethyl vanillin - 0 5  sweet, creamy, vanilla, caramellic
eugenol - 0 5  clove, spicy, sweet, woody
eugenyl acetate - 0 5  carnation, clove, floral, fresh, malty, spicy, sweet, woody
fenchone - 0 2  camphoraceous, earthy, herbal, woody
geraniol - 0 2  citrus, floral, fruity, rose, sweet, waxy
geranyl acetate - 0 5  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 5  cyclamen, fresh, green, hay, ozone, watery
heptanal - 0 2  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 0 2  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone - 0 5  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 2  fatty, fruity, green
hexanal - 0 2  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 2  buttery, sweet
3,4-hexanedione - 0 2  almond, buttery, caramellic, nutty, toasted
1-hexanol - 0 2  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 2  ethereal
(Z)-3-hexen-1-ol - 0 5  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent
hexyl acetate - 0 2  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 2  
isobutylamine - 0 5  cheesy, fishy
d-limonene - 0 5  citrus, orange, fresh, sweet
linalool - 0 5  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 5  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(+)-menthol - 0 5  cooling, mentholic, minty
methyl eugenol - 0 5  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 5  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
methyl salicylate - 0 5  minty, wintergreen
nonanal - 0 5  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
nonanethiol - 0 2  
1-nonanol - 0 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 2  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal - 0 2  aldehydic, citrus, fatty, green, orange, peel, waxy
octanethiol - 0 5  sulfurous
1-octanol - 0 5  aldehydic, green, mushroom, orange, rose, waxy
2-octanone - 0 2  earthy, herbal, natural, weedy, woody
3-octanone - 0 2  fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 5  coconut, oily, fruity
oenanthic acid - 0 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
pelargonic acid - 0 5  cheesy, dairy, dirty, waxy
pentanol - 0 5  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
2-pentanone - 0 2  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 2  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 2  
prenyl acetate - 0 2  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
propanal - 0 5  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 5  acidic, cheesy, pungent, vinegar
pyrazine - 0 5  pungent, sweet, corn, roasted, hazelnut, barley
quinoline - 0 5  earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 5  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 5  bergamot, citrus, herbal, lavender, lime
valeric acid - 0 2  acidic, cheesy, fruity, milky, sharp, sour, tobacco
vanillic acid - 0 2  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
hydroxycitronellal - -0.9091 6  floral, green, lily, melon, sweet, tropical, waxy
triplal - -0.9091 6  green, aldehydic, leafy, cortex, tart, floral, peely
bourgeonal - -1.8182 6  fresh, watery, floral, cyclamen, sweet
florhydral - -1.8182 6  floral, green, muguet, linden_flower, lily_of_the_valley, fresh
7-methoxycitronellal - -1.8182 6  fresh, melon, floral, lily, sweet

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

3.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

4.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

6.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2
×
 
 

Code version:
 

Docker used:
 

Files:
Active model: view 3D download
Inactive model: view 3D download
Active dock: view 3D download
Inactive dock: view 3D download
JSON entry: view   download