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hexanoic acid

SMILES:
CCCCCC(=O)[O-]

Aroma Description:
cheesy, fatty, sour, sweaty1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR51L1 -3.83 7, -5 10, -4.3 12 9.5 7, 2.8182 12  rummy, sweaty, sour, honey, cheesy
OR51I2 -4.4 12, -3.73 14 4.4545 12, 6 14  sour, cheesy, sweaty, acidic
OR51E1 -4.52 12 -  cheesy, sweaty, sour, acidic, rancid
OR2W1 -2.23 3, -4.22 12 8.3333 3, 0 7, 2.6364 12  sweet, herbal, tart, fatty, orange, passionfruit, fresh, mimosa, rancid, mushroom
OR5P2 -5.82 2 0.0427 2  (insufficient data)
OR10A6 -4.3 12 1.9091 12  floral, cinnamyl, honey, rhubarb, neroli, hyacinth, cyclamen, balsamic, cinnamon, dirty
OR52B2 -3.83 14 0.37 14  rancid, cheesy, sour
OR1A1 -1.67 3 3.3333 3, 0 7  passionfruit, herbal, orange, caraway, weedy, hay, spearmint, licorice, plastic, mushroom
OR56A5 -2.83 14 0.9 14  rancid, cheesy, sweaty, buttermilk
OR52D1 - 2.6396 4  anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple
OR4P4 - 1.9231 9  cloth, laundered
OR7D4 - 0.2 6  animal
OR1G1 - 0.0508 4  waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise
OR10J5 - 0 7   
OR2C1 - 0 7   
OR2J2 - 0 7   
OR5P3 - 0 7   
OR5A1 - 0 8   
OR5A2 - 0 8   
OR5AN1 - 0 8   
OR5I1 - 0 9   
OR51E2 - 0 13   

hexanoic acid

SMILES:
CCCCCC(=O)[O-]

Aroma Description:
cheesy, fatty, sour, sweaty

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

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7.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

8.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

9.) Ashti Baghaei, K. (2015). Large scale analysis of olfactory receptors with highly genetically variations in relation with specific anosmia (Doctoral dissertation, Bochum, Ruhr-Universität Bochum, Diss., 2013).

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

12.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

13.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

14.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047