heptanoic acid

SMILES:
CCCCCCC(=O)[O-]

Aroma Description:
rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity1

Receptor log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR56A5 -3.24 8 5 8  rancid, cheesy, sweaty, buttermilk
OR51E1 - 0 5, 4.85 6  cheesy, sweaty, sour, acidic, rancid
OR52B2 -4.56 8 0.3 8  rancid, cheesy, sour
OR52D1 - 4.0609 4  anise, cheesy, rancid, orange, dairy, sour, sweet, tart, sharp, pineapple
OR8D1 -3.58 2 0.0803 2  maple, sugar
OR10S1 - 1.4286 3  watery, cilantro, orange_peel, cumin, orris, aldehydic, greasy, muguet
OR1G1 - 1.269 4  waxy, tart, orange, sweet, aldehydic, medicinal, citrus, clean, fresh, anise
OR10J5 - 0 5   
OR1A1 - 0 5   
OR2C1 - 0 5   
OR2J2 - 0 5   
OR2W1 - 0 5   
OR51L1 - 0 5   
OR5P3 - 0 5   
OR51E2 - 0 7   

heptanoic acid

SMILES:
CCCCCCC(=O)[O-]

Aroma Description:
rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity

Receptor Docking Score Correlated Perceptual Qualities

1.) The Good Scents Company

2.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

3.) Emily A. Yasi, Sara L. Eisen, Hanfei Wang, Widianti Sugianto, Anita R. Minniefield, Kaitlyn A. Hoover, Paul J. Branham, and Pamela Peralta-Yahya Rapid Deorphanization of Human Olfactory Receptors in Yeast Biochemistry 2019, 58, 2160-2166

4.) Guenhael Sanz, Claire Schlegel, Jean-Claude Pernollet and Loic Briand Comparison of Odorant Specificity of Two Human Olfactory Receptors from Different Phylogenetic Classes and Evidence for Antagonism Chemical Senses vol. 30 no. 1 (2005) doi:10.1093/chemse/bji002

5.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

6.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

7.) Christian B. Billesbølle, Claire A. de March, Wijnand J. C. van der Velden, Ning Ma, Jeevan Tewari, Claudia Llinas del Torrent, Linus Li, Bryan Faust, Nagarajan Vaidehi, Hiroaki Matsunami, Aashish Manglik. Structural basis of odorant recognition by a human odorant receptor. bioRxiv 2022.12.20.520951; doi: https://doi.org/10.1101/2022.12.20.520951

8.) Chatelain Pierre, Veithen Alex, Olfactory Receptors involved in the perception of sweat carboxylic acids and the use thereof. WO 2014/191047