leaf alcohol, cis-3-hexen-1-ol, cis-3-hexenol, (Z)-3-hexenol

SMILES:
CC\C=C/CCO

Aroma Description:
fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent1
lettuce2

Receptor Expression log10 EC50 Adj. Top Antagonist? Correlated Perceptual Qualities
OR2W1 53 -5 3, -5.6 4, -3.5 7, -5.7 10 -  sweet, tart, hay, fatty, coumarinic, orange, peony, cinnamon, herbal, tonka
OR2J2 92 -5 3, -4.7 4, -3.3 7, -5.7 10 -  tart, sweet, carnation, hay, orange, warm, cinnamon, clove, coumarinic
OR2J3 100 -5 3, -4.8 4, -3.4 7, -5.61 10 -  tart, hay, sweet, foliage, passionfruit, cinnamon, warm, blackcurrant, coumarinic, candy
OR1A1 73 -3.3 7, -4.05 11 -1.5667 5, 0.1706 7, 10 11  sweet, citrus, fresh, rose, herbal, waxy, orange, spearmint, floral, aldehydic
OR2AG2 100 -5.01 9 -  cinnamyl, sweet, cinnamon, floral, rose, balsamic, hyacinth, honey, magnolia, citrus
OR51T1 76 -3.82 7 2.3529 7  spearmint, dairy, caraway, orangeflower, sharp, neroli, milky, creamy, blueberry, minty
OR14J1 88 -3 3 -  patchouli
OR4S2 57 -3.2 7 0.1529 7  cooked, mimosa, animal, brown, narcissus, rubbery, foliage, vegetable
OR7D4 96 - 0.3 6  animal, citrus, orange, peely, tart, aldehydic, blueberry
OR10G3 96 - 0 5   
OR10G7 80 - 0 5   
OR10J5 84 - 0 5   
OR11A1 100 - 0 5   
OR1C1 100 - 0 5   
OR2A25 100 - 0 5   
OR2B11 100 - 0 5   
OR51E1 100 - 0 5   
OR51L1 88 - 0 5   
OR56A4 100 - 0 5   
OR5K1 100 - 0 5   
OR8D1 96 - 0 5   
OR8K3 92 - 0 5   
OR5A1 100 - 0 8   
OR5A2 100 - 0 8   
OR5AN1 100 - 0 8   
OR10A6 100 - 0 9   
OR11H4 100 - 0 9   
OR7A17 100 - 0 12   
OR5P3 100 - -0.6667 5   
 

leaf alcohol, cis-3-hexen-1-ol, cis-3-hexenol, (Z)-3-hexenol

SMILES:
CC\C=C/CCO

Aroma Description:
fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungentlettuce

Receptor Expr.% Agonist? Dock Score Known agonist Correlated Perceptual Qualities

Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.

1.) The Good Scents Company

2.) Franziska Haag, Antonella Di Pizio, Dietmar Krautwurst, The key food odorant receptive range of broadly tuned receptor OR2W1. Food Chemistry 375 (2022) 131680

3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

4.) Jeremy F. McRae, Joel D. Mainland, Sara R. Jaeger, Kaylin A. Adipietro, Hiroaki Matsunami, and Richard D. Newcomb Genetic Variation in the Odorant Receptor OR2J3 Is Associated with the Ability to Detect the "Grassy" Smelling Odor, cis-3-hexen-1-ol Chem. Senses 37: 585–593, 2012 doi:10.1093/chemse/bjs049

5.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

6.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.

7.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

8.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

9.) Duroux R, Mandeau A, Guiraudie-Capraz G, Quesnel Y, Loing E. A Rose Extract Protects the Skin against Stress Mediators: A Potential Role of Olfactory Receptors. Molecules. 2020 Oct 16;25(20):4743. doi: 10.3390/molecules25204743. PMID: 33081083; PMCID: PMC7587601.

10.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

11.) Keiichi Yoshikawa, Naoko Saito (2016) Method for selecting odor-controlling substance EP3305898B1

12.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y

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