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Olfactory Receptor family 7 subfamily A member 17.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MEPENDTGIS EFVLLGLSEE PELQPFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY FFLSNLSFAD ICFISTTIPK MLINIQTQSR VITYAGCITQ 

       110        120        130        140        150        160        170        180        190        200 
MCFFVLFGGL DSLLLAVMAY DRFVAICHPL HYTVIMNPRL CGLLVLASWM IAALNSLSQS LMVLWLSFCT DLEIPHFFCE LNQVIHLACS DTFLNDMGMY 

       210        220        230        240        250        260        270        280        290        300 
FAAGLLAGGP LVGILCSYSK IVSSIRAISS AQGKYKAFST CASHLSVVSL FCCTGLGVYL TSAATHNSHT SATASVMYTV ATPMLNPFIY SLRNKDIKRA 

       310 
LKMSFRGKQ

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


S T H S    L Y V  L F T D     V M   T I V R      Q I  L E P E  
 A T A    G L G    M D N   L S Q S   G A Y    N I L    F P Q   
Y M V S  T C C F  F Y M G   L S N   Q T I C  M K P I  L G F L  
 A V T    L S V    G A A   L A A I   F C M    T T S    S L F   
L M P T  V S L H  G A L L   M W S   F L V F  I F C I  V L Y M  
 F P N    S A C    L P G   A L V L   L G G    D A F    L V T   
L S Y I  T S F A  L I G V   L G C   L L S D  S L N S  L L N G  
     R    K Y K    Y S C   L R P N   V A L    L F F    L I I   
         G Q A S  V I K S           D Y A M  Y M P T  S I T A  
                   I S S             V F R                 D   
                    I A R           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
arborone -8.46 1 -  woody, ambery, dry
georgywood -7.63 1 -  woody, amber, floral
cedryl acetate -7.02 1 -  dry, woody, cedar, powdery
vetynal -6.61 1 -  woody, dry, earthy, amber, fruity, spicy
(-)-ambroxide -6.61 2 10 2  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
nootkatone - 10 1  grapefruit_peel, citrus, gardenia, woody, grapefruit, orange, sweet, peely, bitter
cedramber -5.88 1 0 3  woody, dry, cedar, ambergris, earthy, vetiver
acetivenol -5.55 1 -  woody
isolongifolanone -5.21 1 -  dry, woody, patchouli, cedar, earthy, tobacco, incense
cedrol -5.04 1 -  cedarwood, woody, dry, sweet, amber, floral, ambrette, musk, powdery
delta-damascone - 8 1  fruity, sweet, rose, natural, petal, currant_bud, black_currant_bud, tobacco
rotundone - 7 1  woody, peppery, agarwood, spicy, guaiacwood
ambroxene oxide -4.056 3 7.155 3  
ambroxene -3.423 3 5.61 3  
vanillin - 5 1  chocolate, creamy, sweet, vanilla
grapefruit mercaptan - 4 1  sulfurous, aromatic, grapefruit, naphthyl, resinous, woody, alliaceous, onion, garlic, tropical
Iso-E-Super -3.926 3 0.658 3  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
patchoulol - 3 1  patchouli, earthy, camphorous, powdery
(R)-(+)-sclareolide - (agonist) 3  dry, paper, woody, ambergris, labdanum
8-drimanol - 0.5 3  
allyl hexanoate - 0 3  sweet, fruity, pineapple, tropical, ethereal, rummy, arrack, fatty, cognac
amber butanol - 0 3  woody, amber, ambrette
amberketal - 0 3  dry, amber, powdery, woody, musk
ambrinol - 0 3  amber, natural, musk, animal
ambrocenide - 0 3  woody, amber, agarwood
benzyl salicylate - 0 3  balsamic, clean, herbal, oily, sweet
citral - 0 3  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coumarin - 0 3  coumarinic, hay, sweet, tonka
gamma-decalactone - 0 3  fresh, oily, waxy, peach, coconut, buttery, sweet
eugenol - 0 3  clove, spicy, sweet, woody
florocyclene - 0 3  fruity, herbal, woody, jasmin, oily, basil
(Z)-3-hexen-1-ol - 0 3  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
karanal - 0 3  dry, dusty, woody, mahogany, amber, resinous, earthy, floral
d-limonene - 0 3  citrus, orange, fresh, sweet
l-limonene - 0 3  terpenic, pine, herbal, peppery
linalool - 0 3  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
(1R,2S,5R)-(-)-menthol - 0 3  peppermint, cooling, mentholic, minty, camphorous, clean, fresh, sweet, herbal
octanal - 0 3  aldehydic, citrus, fatty, green, orange, peel, waxy
okoumal - 0 3  dry, amber, woody, powdery, musk
phenethyl alcohol - 0 3  floral, rose, dried_rose, sweet, fresh, bready, honey
santaliff - 0 3  sandalwood, creamy, woody, milky, waxy, greasy, musk
timberol - 0 3  dry, sawdust, woody, powdery, amber, sandalwood
ysamber K - 0 3  dry, woody, vetiver, amber, powdery, musk, fruity
chloro-ambroxide -4.395 3 -0.11 3  

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

3.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR7A17100 100%F M F V G G S L A N S Q F E L N M A A L A C G Y S S V Y T
OR7A291F M F V I V S L S N S Q F E L N M A A L D Y G Y S S V Y T
OR7A1090 73%F M F L V G N F S N S Q F E I N M A V L G Y C Y S S V Y T
OR10K186 100%Y M F L G S S F G V S T F D I S I L G A L Y A Y K S V Y T
OR7A586 100%V M F I A G N F S Y S Q F E L N I T V L G Y I Y S S V Y T
OR7E2485 96%F M F V A C D M S D S H F D P S I M G F G Y G Y S S V Y T
OR2D385 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR10R284 57%Y M F L A I C L G A S V F D I S I C G V L Y A Y T T V Y T
OR5A184 100%Y F F V G L C L G S S Q F D L P N V V V G F A Y S S V Y S
OR2AG184 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR7D284 88%F V S M P I T L G T S H F E L T I M T L G Y G H S S V Y T
OR7C283 53%F I F I G C N L S G S E F D P S M V T L G Y G Y S S V Y T
OR2V183L I F V V G G L G D G Q F E V Q L C C M L Y A Y R S I Y T
OR6P183 65%Y L F I A C C V G S S K F D I S D L A M I Y T Y R S V Y T
OR8H182 88%Y M F V G A C F S N S N F D T S I L A T L Y M Y R S V Y T
OR8H281 88%Y M F A G T C Y G D S N F D T S I I V T L Y L Y R S V Y T
OR2D280 100%F L F L G C C A G V S D F E A P I M G I L Y A Y K S V Y A
OR6B380 88%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S V Y T
OR2C180 100%F L F L G A C I G N S Q L E V P L V C F T Y A Y A S L Y S
OR5V180 96%Y L F V V G C L G N S H F D I P L T G I G Y A Y I S V Y S
OR6B280 92%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S A Y T
OR10AC180Y M F V G G C F G V S L F D I T L A C L L Y A Y R A L Y T
OR8I280 30%Y M F V V C C F G S S S F D T T S L A T L Y L Y D S V Y T
OR2B1180 100%Y Y F H G C C I G N S Q F E V P L L V F V Y A Y P S L Y S
OR2V280 96%L I F V V G G L G D G Q F E M L I C C M L Y A Y R S I Y T
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