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Olfactory Receptor family 5 subfamily A member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MSITKAWNSS SVTMFILLGF TDHPELQALL FVTFLGIYLT TLAWNLALIF LIRGDTHLHT PMYFFLSNLS FIDICYSSAV APNMLTDFFW EQKTISFVGC 

       110        120        130        140        150        160        170        180        190        200 
AAQFFFFVGM GLSECLLLTA MAYDRYAAIS SPLLYPTIMT QGLCTRMVVG AYVGGFLSSL IQASSIFRLH FCGPNIINHF FCDLPPVLAL SCSDTFLSQV 

       210        220        230        240        250        260        270        280        290        300 
VNFLVVVTVG GTSFLQLLIS YGYIVSAVLK IPSAEGRWKA CNTCASHLMV VTLLFGTALF VYLRPSSSYL LGRDKVVSVF YSLVIPMLNP LIYSLRNKEI 

       310        320 
KDALWKVLER KKVFS

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D R G L     S P   L F T D     I S   S I T K      F F  L E P H  
 V V K   R L Y V   V Q S   S A Q I   G V F    D T L    L A Q   
Y F V S   F L A   L F N V   L S S   Q A A C  M N P A  T V F L  
 V L S   T G F L   V V V   L F G G   F F F    V A S    G L F   
L M P I   L T V   G G V T   V Y A   M G V F  S Y C I  T L Y I  
 L P N   V M L H   F S T   G V V M   S L G    D I F    A L T   
    Y I   S A C   L L Q L   R T C   L L C E  S L N S  A L N W  
         T N C A   Y S I   L G Q T   A T L    L F F    F I L   
          K W R   V I Y G           D Y A M  Y M P T  G R I L  
         G E A S   V A S             A Y R                 D   
                    I K L           S S I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
ambrinol - 10 1  amber, natural, musk, animal
beta-ionone -5.35 2 10 2  beeswax, berry, floral, fruity, sweet, tropical, woody, fragrant, sour, acid, vinegar, sharp, pungent
ysamber K - 0.5 1  dry, woody, vetiver, amber, powdery, musk, fruity
acetic acid - 0 1  sharp, pungent, sour, vinegar
acetophenone - 0 1  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
amber butanol - 0 1  woody, amber, ambrette
amber xtreme - 0 1  animal, musk, woody, spicy
amberketal - 0 1  dry, amber, powdery, woody, musk
ambrettolide - 0 1  sweet, soapy, musk, amber, fruity, berry
(-)-ambroxide - 0 1  dry, amber, ambergris, paper, musk, woody, cedar, pine, green, seedy
benzoic acid - 0 1  balsamic, urine
benzyl propionate - 0 1  sweet, fruity, floral, banana, jasmin, balsamic, apple, jammy
boisambrene - 0 1  woody, cedar, ambergris, dry, dusty, amber
borneol - 0 1  pine, woody, camphorous, peppery, earthy, minty, herbal, musty
p-t-butyl cyclohexanone - 0 1  woody, minty, patchouli, musk, leathery
calone - 0 1  fresh, watery, clean, melon, green, marine, ozone, phenolic
camphene - 0 1  woody, herbal, fir_needle
camphor - 0 1  camphorous
caproic acid - 0 1  cheesy, fatty, sour, sweaty
caprylic acid - 0 1  cheesy, fatty, oily, rancid, vegetable, waxy
(R)-(-)-carvone - 0 1  herbal, minty, spearmint, sweet
celestolide - 0 1  ambergris, animal, cedar, musk, woody
1,4-cineol - 0 1  cooling, pine, minty, camphorous, terpenic, green
civetone - 0 1  clean, musk, dry, animal, sweet
claritone - 0 1  sweet, herbal, clary_sage, sage, bergamot, petitgrain, tropical, citrus
cosmone - 0 1  ambergris, animal, anisic, cloth, fatty, laundered, musk, powdery, woody
p-cresyl phenyl acetate - 0 1  animal, rose, honey, narcissus, lily, hyacinth
cyclododecanone - 0 1  
cyclopentadecane - 0 1  
cyclopentadecanol - 0 1  musk
cyclopentadecanone - 0 1  animal, greasy, musk, natural, powdery
beta-damascone - 0 1  berry, currant, floral, fruity, honey, plum, rose, tobacco
gamma-decalactone - 0 1  fresh, oily, waxy, peach, coconut, buttery, sweet
decanal - 0 1  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 1  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
delta-dodecalactone - 0 1  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
1-dodecanol - 0 1  earthy, soapy, waxy, fatty, honey, coconut, clean, aldehydic, cilantro, watery, greasy
omega-dodecanolactam - 0 1  
ethylene brassylate - 0 1  ambrette, floral, musk, powdery, sweet, woody
exaltolide - 0 1  animal, fruity, musk, natural, powdery
fructone - 0 1  apple, fruity, green, plum, sweet, tropical, woody
galaxolide - 0 1  floral, musk, sweet
geraniol - 0 1  citrus, floral, fruity, rose, sweet, waxy
globanone - 0 1  animal, balsamic, cloth, dry, floral, laundered, musk, tobacco, waxy
habanolide - 0 1  animal, cloth, dry, laundered, metallic, musk, powdery, sweet, tropical, waxy
helional - 0 1  cyclamen, fresh, green, hay, ozone, watery
helvetolide - 0 1  musk, ambrette, fruity, pear, woody, floral
hexanal - 0 1  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
hexanol - 0 1  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
(Z)-3-hexen-1-ol - 0 1  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
(Z)-3-hexenyl hexanoate - 0 1  fruity, green, waxy, pear, winey, tropical, grassy, pineapple
Iso-E-Super - 0 1  ambergris, cedar, dry, ketonic, old_wood, phenolic, woody
isoamyl butyrate - 0 1  fruity, green, apricot, pear, banana
isoborneol - 0 1  balsamic, camphorous, herbal, woody
isobornyl acetate - 0 1  balsamic, camphorous, herbal, woody, sweet, citrus, soapy, terpenic, pine
isolongifolanone - 0 1  dry, woody, patchouli, cedar, earthy, tobacco, incense
isomenthone - 0 1  minty, cooling, peppermint, sweet
isovaleric acid - 0 1  cheesy, sour, sweaty, tropical
jasmolactone delta - 0 1  oily, fruity, coconut, floral, petal, jasmine, tuberose, peach, apricot
d-limonene - 0 1  citrus, orange, fresh, sweet
melonal - 0 1  fresh, ozone, melon, watermelon, sweet, clean, green
(1R,2S,5R)-(-)-menthol - 0 1  peppermint, cooling, mentholic, minty, camphorous, clean, fresh, sweet, herbal
methyl cinnamate - 0 1  balsamic, cherry, strawberry, sweet
methyl nonyl acetaldehyde - 0 1  fresh, amber, aldehydic, mossy, citrus, tuberose, metallic, waxy, coumarinic
6-methyl quinoline - 0 1  leathery, tonka, castoreum, tobacco, civet, fecal
muscenone - 0 1  animal, musk, soapy
muscone - 0 1  musk, animal, powdery
musk ketone - 0 1  dry, fatty, floral, musk, powdery, soapy
musk xylene - 0 1  dry, fatty, musk, soapy, sweet
gamma-nonalactone - 0 1  buttery, coconut, creamy, oily, sweet, waxy
gamma-octalactone - 0 1  sweet, coconut, waxy, creamy, tonka, dairy, fatty
octanal - 0 1  aldehydic, citrus, fatty, green, orange, peel, waxy
1-octanol - 0 1  aldehydic, green, mushroom, orange, rose, waxy
oranger crystals - 0 1  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
orris hexanone - 0 1  woody, dry, orris, earthy, camphorous
2-pentadecanone - 0 1  burnt, celery, fatty, fresh, jasmine, oily, waxy
8-pentadecanone - 0 1  
phenethyl acetate - 0 1  floral, fruity, honey, rose, sweet, tropical
phenylacetic acid - 0 1  sweet, honey, floral, honeysuckle, sour, waxy, civet
piperonyl acetone - 0 1  berry, candy, cotton, floral, fruity, heliotrope, jammy, powdery, raspberry, sweet
raspberry ketone - 0 1  berry, floral, jammy, raspberry, ripe, seedy, sweet, woody
romandolide - 0 1  musk, ambrette, fruity, berry
santaliff - 0 1  sandalwood, creamy, woody, milky, waxy, greasy, musk
(R)-(+)-sclareolide - 0 1  dry, paper, woody, ambergris, labdanum
styralyl acetate - 0 1  green, leafy, gardenia, rhubarb, musty
sulcatone - 0 1  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
alpha-terpinene - 0 1  woody, terpenic, lemon, herbal, medicinal, citrus
tonalide - 0 1  amber, ambrette, fruity, musk, powdery, sweet
tonka undecanone - 0 1  sweet, spicy, balsamic, tonka, woody, tobacco, green
gamma-undecalactone - 0 1  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
valeric acid - 0 1  acidic, cheesy, fruity, milky, sharp, sour, tobacco
gamma-valerolactone - 0 1  herbal, sweet, warm, tobacco, cocoa, woody
woody cyclohexanone - 0 1  woody, old_wood, amber, tobacco, herbal

1.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]

2.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR5A1100 100%Y F F V G L C L G S S Q F D L P N V V V G F A Y S S V Y S
OR5A288 100%Y Y F C G L C F G S S E F D L P T V S V G Y G Y S S I Y A
OR2D386 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR6P185 65%Y L F I A C C V G S S K F D I S D L A M I Y T Y R S V Y T
OR2B1184 100%Y Y F H G C C I G N S Q F E V P L L V F V Y A Y P S L Y S
OR7A1784 100%F M F V G G S L A N S Q F E L N M A A L A C G Y S S V Y T
OR5V183 96%Y L F V V G C L G N S H F D I P L T G I G Y A Y I S V Y S
OR5AN183 100%Y Y F S G L S C G A S Q F D M P T L T F G Y G Y S S V Y T
OR2AG183 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR8I283 30%Y M F V V C C F G S S S F D T T S L A T L Y L Y D S V Y T
OR2D283 100%F L F L G C C A G V S D F E A P I M G I L Y A Y K S V Y A
OR2AE182 100%H H Y L G G C F A N S H Y E F P T I S L L F C Y R S V Y S
OR6B382 88%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S V Y T
OR11L182 100%Y L F V G A C F G T G P F D L P I L S V L Y M Y S S V Y T
OR2C182 100%F L F L G A C I G N S Q L E V P L V C F T Y A Y A S L Y S
OR6B282 92%Y L F S V C C V G I S K F D I S D L A I L Y L Y Q S A Y T
OR5G382S M F G E A C F A S T H F D I F L L A I G Y L Y S S L Y T
OR2B382 42%Y L F L G A C L G N S Q F E V P L F S I L Y A Y P S L Y G
OR2M582 34%L I Y V L G C F G D A D F D F P L C C M I Y G Y T S V Y T
OR9I182 96%Y F F T A G C F G G A R F D L P I F G V I F L Y S S V Y T
OR9Q182 96%Y F F T G S C Y G S A R F D L P I F A V I F L Y N S V Y T
OR2V282 96%L I F V V G G L G D G Q F E M L I C C M L Y A Y R S I Y T
OR9Q281 100%Y F F T A S C Y G S A R F D L P I F A V M F L Y N S V Y T
OR7A1081 73%F M F L V G N F S N S Q F E I N M A V L G Y C Y S S V Y T
OR2T1281 69%L I L P G G C F G D G Q F E A P M C C M L Y G Y K S A Y T
OR10J181 80%Y M F V G I C F G V A Q F D I R T I S V L Y A Y K S V Y T
OR10J381 26%Y L Y L G I C F G M A Q F D V R N V S V L Y A Y K S V Y T
OR10R281 57%Y M F L A I C L G A S V F D I S I C G V L Y A Y T T V Y T
OR2W381 100%F L F L G G C L G N S M L E M P V L A V V Y I Y G M L Y N
OR6B181 100%Y L F I M C C V G I S K F D I S D L A I F Y I Y R S I Y A
OR7A281F M F V I V S L S N S Q F E L N M A A L D Y G Y S S V Y T
OR10AG181 65%Y M F L G G C L T V V E F D I P V V A F I F G Y K S L Y T
OR10J480Y L Y L G V C F G T A Q F D I R T I S V L Y T Y K S V Y T
OR2G680 100%F L A M G S C I G T S Q F E V P L A S F L Y I Y A S L Y T
OR6Y180 92%Y L F V V C Y I G T A K F D I S D L A V I Y T Y K S V Y T
OR10W180 100%Y M F I G S C F G L S L F D V P V A A A I Y C Y S S L Y T
OR11A180 100%Y F F G A T C L G V D V Y D F M T L S C L Y L Y S S L Y T
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