Olfactory Receptor family 8 subfamily B member 12.
Estimated Expression: 92% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MAAKNSSVTE FILEGLTHQP GLRIPLFFLF LGFYTVTVVG NLGLITLIGL NSHLHTPMYF FLFNLSLIDF CFSTTITPKM LMSFVSRKNI ISFTGCMTQL 110 120 130 140 150 160 170 180 190 200 FFFCFFVVSE SFILSAMAYD RYVAICNPLL YTVTMSCQVC LLLLLGAYGM GFAGAMAHTG SIMNLTFCAD NLVNHFMCDI LPLLELSCNS SYMNELVVFI 210 220 230 240 250 260 270 280 290 300 VVAVDVGMPI VTVFISYALI LSSILHNSST EGRSKAFSTC SSHIIVVSLF FGSGAFMYLK PLSILPLEQG KVSSLFYTII VPVLNPLIYS LRNKDVKVAL 310 RRTLGRKIFS
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 G Q E L K L Y M M Y S S I S S I I N V F L G P Q S V K F A G L E N G T H A G T F S M L P I R Y F L S S G F F I F V V M A G Q T M C M K P T L F F L I I T L S V A V V A F G M F F L I T T G L F L V P V V I I H G V D V G Y A F F C F S F C F V T Y F L P N S S C I P M G L L L S V V D I L V V T L S Y I T S F A F V T V L L C I F S E S L N F G L N G K S R Y S I V Q C S A S L L F F T I L G E T S L I L A D Y A M Y M P T L G I L I S S V Y R N N H L N C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| (1R,2S,5R)-(-)-menthol | - | (probable agonist) | peppermint, cooling, mentholic, minty, camphorous, clean, fresh, sweet, herbal | |
| (1S,2R,5S)-(+)-menthol | - | (probable agonist) | cooling, mentholic, minty, fresh, sweet, herbal |
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR8B12 | 100 | 92% | F | L | F | C | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | V | F | G | Y | L | S | L | Y | T |
| OR8B8 | 96 | 100% | Y | L | F | L | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | I | F | G | Y | F | S | L | Y | T |
| OR8B2 | 93 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 93 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8D4 | 90 | 96% | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR8G1 | 85 | 88% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | L | I | V | G | N | I | F | A | Y | S | S | V | Y | T |
| OR8D1 | 84 | 96% | Y | L | F | V | V | V | G | Y | G | S | A | H | F | D | V | L | L | I | A | N | T | F | I | Y | P | S | V | Y | T |
| OR8D2 | 83 | 46% | Y | L | F | L | V | I | G | Y | G | W | A | H | F | D | I | L | L | I | G | N | T | F | I | Y | P | S | V | Y | I |
| OR1J1 | 82 | 100% | F | T | F | I | A | D | S | F | A | C | A | H | F | D | L | G | I | A | A | A | I | Y | I | Y | P | S | V | Y | T |
| OR8B4 | 82 | 61% | Y | L | F | C | V | N | C | Y | G | G | A | H | L | D | V | L | F | V | V | I | T | F | G | Y | T | S | V | Y | T |
| OR5R1 | 82 | 34% | Y | L | F | L | M | I | C | F | S | V | A | H | Y | D | D | L | I | F | A | D | M | Y | L | Y | K | S | V | Y | T |
| OR5B21 | 81 | 100% | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |
| OR2AG1 | 81 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR10K2 | 81 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR8G5 | 81 | 100% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | I | I | F | S | N | I | F | A | Y | S | S | V | Y | T |
| OR9I1 | 81 | 96% | Y | F | F | T | A | G | C | F | G | G | A | R | F | D | L | P | I | F | G | V | I | F | L | Y | S | S | V | Y | T |
| OR8U8 | 80 | Y | L | F | L | M | V | S | L | S | M | A | H | Y | D | D | M | I | C | A | T | F | Y | L | Y | S | S | V | Y | T |