Olfactory Receptor family 8 subfamily B member 8.
Estimated Expression: 100% of the population.
Expression estimate based on data from Verbeurgt et al (2014).
Sequence:
10 20 30 40 50 60 70 80 90 100 MAAENSSFVT QFILAGLTDQ PGVQIPLFFL FLGFYVVTVV GNLGLITLIR LNSHLHTPMY FFLYNLSFID FCYSSVITPK MLMSFVLKKN SISYAGCMTQ 110 120 130 140 150 160 170 180 190 200 LFFFLFFVVS ESFILSAMAY DRYVAICNPL LYMVTMSPQV CFLLLLGVYG MGFAGAMAHT ACMMGVTFCA NNLVNHYMCD ILPLLECACT STYVNELVVF 210 220 230 240 250 260 270 280 290 300 VVVGIDIGVP TVTIFISYAL ILSSIFHIDS TEGRSKAFST CSSHIIAVSL FFGSGAFMYL KPFSLLAMNQ GKVSSLFYTT VVPMLNPLIY SLRNKDVKVA 310 320 LKKILNKNAF S
Transmembrane Helices:
TMR7 TMR6 TMR5 TMR4 TMR3 TMR2 TMR1 G Q N M K L Y M V Y T S M C S I S N V F V G P Q S V K F A G L E N A T H A G A Y S M L P I Q Y F L S S G F F V F V V M A G Q T M C M K P T L F F L V T T L S V G V V A F G M F F L I V S G L F L M P V A I I H G I D I G Y V F F L F S Y C F V V Y F L P N S S C T P V G L L L S V V D I F V V T L S Y I T S F A F I T V L F C I F S E S L N Y G L N G K S R Y S I V Q P S A S L L F F T I L G E T S L I L A D Y A M Y M P T L R I L I S S V Y R N I H F N C I A UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| (1R,2S,5R)-(-)-menthol | - | (probable agonist) | peppermint, cooling, mentholic, minty, camphorous, clean, fresh, sweet, herbal | |
| 2-decenal | -2.77 1 | 0.3236 1 | waxy, fatty, earthy, green, cilantro, mushroom, aldehydic, fried, chicken_fat, tallow | |
| ethyl vanillin | -2.63 1 | 0.2792 1 | sweet, creamy, vanilla, caramellic | |
| hexanal | - | 0.5 2 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| (1S,2R,5S)-(+)-menthol | - | (probable agonist) | cooling, mentholic, minty, fresh, sweet, herbal |
1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
2.) Ojiro I, Katsuyama H, Kaneko R, Ogasawara S, Murata T, Terada Y, et al. (2024) Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors. PLoS ONE 19(6): e0306029. https://doi.org/10.1371/journal.pone.0306029
| Prot. | Sim. | Expr. | 2.53 | 3.29 | 3.32 | 3.33 | 3.36 | 3.37 | 3.40 | 3.41 | 4.53 | 4.56 | 4.57 | 4.60 | 45.49 | 45.51 | 45.52 | 45.53 | 5.39 | 5.42 | 5.43 | 5.46 | 5.47 | 6.48 | 6.51 | 6.55 | 6.59 | 7.38 | 7.39 | 7.41 | 7.42 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR8B8 | 100 | 100% | Y | L | F | L | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | I | F | G | Y | F | S | L | Y | T |
| OR8B12 | 96 | 92% | F | L | F | C | V | V | S | F | G | G | A | H | M | D | I | L | V | V | V | D | V | F | G | Y | L | S | L | Y | T |
| OR8B2 | 96 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8B3 | 96 | 88% | Y | L | F | L | V | I | C | Y | G | G | A | H | L | D | I | L | V | V | V | N | I | F | A | Y | Y | S | V | Y | T |
| OR8D4 | 88 | 96% | Y | L | F | C | V | I | C | Y | G | D | A | H | F | D | I | V | I | I | G | N | M | Y | L | Y | A | S | V | Y | T |
| OR8G1 | 87 | 88% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | L | I | V | G | N | I | F | A | Y | S | S | V | Y | T |
| OR8D1 | 85 | 96% | Y | L | F | V | V | V | G | Y | G | S | A | H | F | D | V | L | L | I | A | N | T | F | I | Y | P | S | V | Y | T |
| OR8D2 | 84 | 46% | Y | L | F | L | V | I | G | Y | G | W | A | H | F | D | I | L | L | I | G | N | T | F | I | Y | P | S | V | Y | I |
| OR5R1 | 84 | 34% | Y | L | F | L | M | I | C | F | S | V | A | H | Y | D | D | L | I | F | A | D | M | Y | L | Y | K | S | V | Y | T |
| OR1J1 | 83 | 100% | F | T | F | I | A | D | S | F | A | C | A | H | F | D | L | G | I | A | A | A | I | Y | I | Y | P | S | V | Y | T |
| OR10K2 | 83 | 96% | Y | M | F | L | G | C | S | F | G | V | A | I | F | D | I | A | I | L | C | V | L | Y | A | Y | Q | S | V | Y | T |
| OR5B21 | 83 | 100% | Y | F | F | V | A | T | C | Y | G | N | A | H | F | D | I | P | V | V | A | N | V | Y | I | Y | N | S | V | Y | T |
| OR8G5 | 82 | 100% | H | L | F | L | A | I | C | H | G | C | A | H | F | D | L | I | I | F | S | N | I | F | A | Y | S | S | V | Y | T |
| OR2AG1 | 82 | 100% | F | M | A | L | G | G | D | L | A | S | A | Y | L | E | I | P | V | M | G | F | L | Y | A | Y | S | S | V | Y | T |
| OR8U8 | 82 | Y | L | F | L | M | V | S | L | S | M | A | H | Y | D | D | M | I | C | A | T | F | Y | L | Y | S | S | V | Y | T | |
| OR5B3 | 82 | 88% | Y | M | F | V | A | T | N | Y | G | N | A | H | F | D | I | P | L | V | V | N | I | Y | I | Y | S | P | V | Y | T |
| OR8G2 | 81 | 61% | H | L | F | L | A | I | C | H | G | G | S | H | F | D | L | F | V | L | S | N | I | F | A | Y | S | S | V | Y | T |
| OR10AG1 | 81 | 65% | Y | M | F | L | G | G | C | L | T | V | V | E | F | D | I | P | V | V | A | F | I | F | G | Y | K | S | L | Y | T |
| OR8B4 | 80 | 61% | Y | L | F | C | V | N | C | Y | G | G | A | H | L | D | V | L | F | V | V | I | T | F | G | Y | T | S | V | Y | T |
| OR8A1 | 80 | 69% | Y | L | F | L | V | I | C | Y | G | G | S | E | F | D | I | L | V | S | A | N | I | Y | T | Y | P | S | V | Y | T |
| OR14L1 | 80 | Y | A | F | M | A | T | V | A | G | C | G | H | F | N | I | P | V | F | G | L | V | M | G | Y | I | S | A | Y | T | |
| OR2AG2 | 80 | 100% | F | M | A | L | G | S | D | L | A | I | A | H | L | E | I | P | I | T | G | F | L | Y | A | Y | S | S | V | Y | T |