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Olfactory Receptor family 2 subfamily AG member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MELWNFTLGS GFILVGILND SGSPELLCAT ITILYLLALI SNGLLLLAIT MEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 

       110        120        130        140        150        160        170        180        190        200 
MFLALTMGGA EDLLLAFMAY DRYVAICHPL TYMTLMSSRA CWLMVATSWI LASLSALIYT VYTMHYPFCR AQEIRHLLCE IPHLLKVACA DTSRYELMVY 

       210        220        230        240        250        260        270        280        290        300 
VMGVTFLIPS LAAILASYTQ ILLTVLHMPS NEGRKKALVT CSSHLTVVGM FYGAATFMYV LPSSFHSTRQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 

       310        320 
LRRVLGKYML PAHSTL

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


D Q R T       F   R S T D     T Y   S I T N      L F  S G S D  
 I I N   S S P L   L E Y   V T Y I   G G F    D A L    L E P   
Y F V S   V Y M   V Y V M   L A S   Q L A C  A K P T  T A C L  
 V I T   F T A A   V G M   L S A L   L F M    V V S    I T I   
L A P T   G Y F   I L F T   I W S   M T L A  T F L L  L L Y L  
 L P N   M G V V   L S P   T A V M   A G G    D M L    I L A   
    Y I   T L H   L I A A   L W C   L L D E  S L Q G  L G N S  
         S S C T   Y S A   A R S S   F A L    L L L    L L L   
          V L A   L I Q T           D Y A M  Y M P M  M T I A  
         K K R G   V T L             V Y R                 E   
                    M H L           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB 2
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
bean pyrazine -6.7 1 7.8632 1  green_pea, earthy, beany, chocolate, nutty
phenoxyethyl isobutyrate - 10 2  sweet, fruity, tropical, rose, honey, floral, waxy, green, apple, powdery
2-sec-butyl-3-methoxypyrazine -6.4 1 7.094 1  musty, green, pea, galbanum, bell, pepper
isoamyl acetate - 8.617 2  banana, fruity, solvent, sweet
galbanum pyrazine -6.1 1 6.7521 1  green_pea, bell_pepper, green, galbanum
2-ethyl pyridine -4 1 10 1  green, grassy
phenethyl acetate - 7.9787 2  floral, fruity, honey, rose, sweet, tropical
isoamyl benzoate - 7.6596 2  balsamic, green, sweet, waxy
prenyl acetate - 7.5532 2  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
n-amyl butyrate -0.65 3 10 3  sweet, fruity, banana, pineapple, cherry, tropical
earthy pyrazine -4 1 1.8803 1  raw_potato, earthy, green, bell_pepper, nutty
2-isobutyl-3-methylpyrazine -3.8 1 2.1368 1  herbal, green, sugar
2-isobutylthiazole -4.2 1 1.1966 1  green, wasabi, privet, tomato, leaf, earthy, vegetable, metallic
shoyu pyrazine -3 1 0.6838 1  nutty, pepper, raw
androstadienone -1.5 4 0.0494 4  animal, musky
o-isopropylanisole - 0.0588 5  
acetic acid - 0 3  sharp, pungent, sour, vinegar
2-acetyl-3,5-dimethyl pyrazine - 0 1  nutty, hazelnut, roasted_hazelnut
almond pyrazine - 0 1  roasted, almond, hazelnut, peanut
butyl butyrate - 0 3  fruity, banana, pineapple, green, cherry, tropical_fruit, ripe_fruit, juicy_fruit, sweet, fresh, ripe
2,5-dimethyl pyrazine - 0 1  cocoa, nutty, roasted, beefy, woody, grassy, medicinal
2,6-dimethylpyrazine - 0 1  ethereal, cocoa, nutty, roasted, meaty, roasted_meaty, beefy, brown, coffee, buttermilk
ethanol - 0 3  alcoholic, ethereal, fruity
3-ethyl pyridine - 0 1  tobacco, oakmoss, leathery, caramellic, roasted, hazelnut
2-ethyl-3,5-dimethylpyrazine - 0 1  almond, burnt, caramellic, cocoa, coffee, musty, nutty, peanut, roasted
filbert pyrazine - 0 1  nutty, peanut, musty, corn, raw, earthy, bready
hazelnut pyrazine - 0 1  earthy, green, hazelnut, meaty, musty, nutty, potato, roasted, toasted, vegetable
helional - 0 3  cyclamen, fresh, green, hay, ozone, watery
hexyl butyrate - 0 3  green, sweet, fruity, apple, waxy, soapy, estery, vegetable
hydrochloric acid - 0 3  sharp, pungent, sour, irritating, chlorine, meaty
2,4-lutidine - 0 1  smoky, phenolic
2,5-lutidine - 0 1  roasted, green, earthy
2-methoxy-3,5-dimethylpyrazine - 0 1  earthy
methyl alcohol - 0 3  alcoholic
methyl isoeugenol - 0 1  spicy, clove, floral, carnation, woody
6-methyl quinoline - 0 1  leathery, tonka, castoreum, tobacco, civet, fecal
2-methylthio-3-methylpyrazine - 0 1  roasted, meaty, nutty, almond, vegetable
phenylpropyl alcohol - 0 3  sweet, spicy, cinnamyl, floral, hyacinth, balsamic, cinnamon, fruity, honey, winey
piperonal - 0 3  maraschino_cherry, bitter_almond, cherry, tropical, custard, vanilla, spicy, sweet, creamy, cinnamyl
propyl butyrate - 0 3  fruity, sweet, apricot, pineapple, rancid, sweaty
safrole - 0 3  anise, floral, sassafrass, spicy, sweet, warm, woody
1,2,4-trimethylbenzene - 0 1  
2,3,5-trimethylpyrazine - 0 1  nutty, nut_skin, earthy, powdery, cocoa, potato, baked_potato, peanut, roasted_peanut, hazelnut, musty
2,3,5-trimethylpyridine - 0 1  
2-ethyl pyrazine -3.5 5 -0.5882 5  peanut, butter, musty, nutty, woody, roasted, cocoa, fermented, meaty

1.) Françoise, W., Philippeau, M., Veithen, A., Chatelain, P., & Quesnel, Y. (2016, May). Functional characterization of human olfactory receptors responding to pyrazine odorants. In CHEMICAL SENSES (Vol. 41, No. 4, pp. 433-434). GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND: OXFORD UNIV PRESS.

2.) Gelis L, Wolf S, Hatt H, Neuhaus EM, Gerwert K. Prediction of a ligand-binding niche within a human olfactory receptor by combining site-directed mutagenesis with dynamic homology modeling. Angew Chem Int Ed Engl. 2012 Jan 27;51(5):1274-8. doi: 10.1002/anie.201103980. Epub 2011 Dec 5. PMID: 22144177.

3.) Kwon, O. S., Song, H. S., Park, S. J., Lee, S. H., An, J. H., Park, J. W., Yang, H. H., Yoon, H., Bae, J., Park, T. H. and Jang, J. (2015), An Ultrasensitive, Selective, Multiplexed Superbioelectronic Nose That Mimics the Human Sense of Smell, Nano Lett., 15: 6559-6567.

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) Chatelain P., Wilkin F., Veithen A., Philippeau M., Noiset O., Quesnel Y. Sensorial Chemistry: Functional characterization and structure-activity relationship understanding of OR5K1 and OR2AG1 allow to design and synthetize new selective compounds. Chem. Senses. 2017;42:e28.
Prot.Sim.Expr.2.53 3.29 3.32 3.33 3.36 3.37 3.40 3.41 4.53 4.56 4.57 4.60 45.49 45.51 45.52 45.53 5.39 5.42 5.43 5.46 5.47 6.48 6.51 6.55 6.59 7.38 7.39 7.41 7.42
OR2AG1100 100%F M A L G G D L A S A Y L E I P V M G F L Y A Y S S V Y T
OR7G288 80%L I V L A G N C S N A L F E L A I A A F G Y G Y S S V Y S
OR2AG288 100%F M A L G S D L A I A H L E I P I T G F L Y A Y S S V Y T
OR10P187 80%Y M F I G I C C G T A H L D I L V A T F I F A Y Q S L Y T
OR11L187 100%Y L F V G A C F G T G P F D L P I L S V L Y M Y S S V Y T
OR2T486 80%Y M Y V A G F F G D G F F E V P M C C M L Y A Y S S V Y T
OR7G386F I V L V G N G S D A H F E L A V V T L G Y G Y S S V Y T
OR2T1086 92%Y M Y L G G C C G D G L F E V P M C C M L Y A Y S S F Y T
OR2T586 100%Y M Y L A G F F G D G L F E V P M C C M L Y A Y S S V Y T
OR2T2986 100%Y M Y L A G F F G D G L F E V P M C C M L Y A Y S S V Y T
OR2T1186 96%F I Y L I G F F G D G L F E I P M C C M L Y A Y Q S A Y T
OR2T1285 69%L I L P G G C F G D G Q F E A P M C C M L Y G Y K S A Y T
OR10K285 96%Y M F L G C S F G V A I F D I A I L C V L Y A Y Q S V Y T
OR10AD185 100%F M V F G V C I G N G L F E A P I D A V I Y A Y H S L Y T
OR2M584 34%L I Y V L G C F G D A D F D F P L C C M I Y G Y T S V Y T
OR7G184 61%L I V L A G S C S D A Q F E V V I A S F G Y A Y S S V Y T
OR10AG184 65%Y M F L G G C L T V V E F D I P V V A F I F G Y K S L Y T
OR7A1784 100%F M F V G G S L A N S Q F E L N M A A L A C G Y S S V Y T
OR2V284 96%L I F V V G G L G D G Q F E M L I C C M L Y A Y R S I Y T
OR8B283 88%Y L F L V I C Y G G A H L D I L V V V N I F A Y Y S V Y T
OR8B383 88%Y L F L V I C Y G G A H L D I L V V V N I F A Y Y S V Y T
OR5B2183 100%Y F F V A T C Y G N A H F D I P V V A N V Y I Y N S V Y T
OR2D383 100%F I F L G C C A G V S D F E P P I M G I L Y G Y N S V Y T
OR5A183 100%Y F F V G L C L G S S Q F D L P N V V V G F A Y S S V Y S
OR2M482 96%L I Y V L G C F G D G V F D V A L C C M L Y A Y A S A Y T
OR2T882 96%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
OR2T3382 92%L I L P G G C F G D G Q F E T P M C C M L Y A Y K S A Y T
OR2W382 100%F L F L G G C L G N S M L E M P V L A V V Y I Y G M L Y N
OR2M782 34%L I Y I L G C F G D G D C D F P I C C M L Y G C T S V Y T
OR8B882 100%Y L F L V V S F G G A H M D I L V V V D I F G Y F S L Y T
OR8G182 88%H L F L A I C H G C A H F D L L I V G N I F A Y S S V Y T
OR5B382 88%Y M F V A T N Y G N A H F D I P L V V N I Y I Y S P V Y T
OR7E2482 96%F M F V A C D M S D S H F D P S I M G F G Y G Y S S V Y T
OR8D482 96%Y L F C V I C Y G D A H F D I V I I G N M Y L Y A S V Y T
OR2M282 100%L I Y I S G C F G D G D F E F P I C C M L Y A Y T S V Y T
OR2T3581Y I L L I G F F G D G L F E I P M C C M L Y A N H S A Y T
OR5C181 100%Y M F A A D C C G S A H F D I P L I C I Q Y L Y S S V Y T
OR1A181 73%F M M I G N S Y G N A H Y D I T M L G I F Y V Y L T V Y T
OR2M381 100%L I Y T L G C F G D G D F D F P L C C M I Y A Y T S V Y T
OR2C181 100%F L F L G A C I G N S Q L E V P L V C F T Y A Y A S L Y S
OR5V181 96%Y L F V V G C L G N S H F D I P L T G I G Y A Y I S V Y S
OR2G381 80%F L S L G S C I G S S H I E V P L V S F V Y I Y S S L Y T
OR5AP281 61%Y F F G L G C F G N A H Y D T P I F S I V F I Y T S V Y T
OR5AR181 53%Y F F V V D C Y G S L H F E I P L L C I E Y V Y T S V Y T
OR6C281 100%F I V I G A F F G I I P S D A G V M A A L Y C Y S S V T T
OR8B1281 92%F L F C V V S F G G A H M D I L V V V D V F G Y L S L Y T
OR2T281Y I Y L I G F F G D G L F E I P M C C M L Y A N H S A Y T
OR2T681 92%Y C Y M M G F F G D S L F E A P M C C M L Y A Y Q S A Y T
OR2V181L I F V V G G L G D G Q F E V Q L C C M L Y A Y R S I Y T
OR10A381 100%F M I L G G C F G V A Q F E T P A G T I V Y A Y K S L Y T
OR8J380 96%N L F L I V V M G T A V Y D I A V S A N L Y M Y Q S V Y T
OR10R280 57%Y M F L A I C L G A S V F D I S I C G V L Y A Y T T V Y T
OR1J480 100%L M F I T D N F S N A H F D L V I V G V I Y I Y S S V Y T
OR7A1080 73%F M F L V G N F S N S Q F E I N M A V L G Y C Y S S V Y T
OR8U180 80%Y L F L M I S L S M A H Y D D M I C A M F Y L Y S S V Y T
×
 
 

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