(-)-menthol, l-menthol
SMILES:
C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C
Aroma Description:
peppermint, cooling, mentholic, minty, camphorous, clean1
minty, fresh, sweet, herbal2
| Receptor | Expression | log10 EC50 | Adj. Top | Antagonist? | Correlated Perceptual Qualities |
|---|---|---|---|---|---|
| OR8K3 | 92 | -3.8 7, -3.93 8 | - | natural, sugar, mentholic, plum, petal, tobacco | |
| OR10X1 | 38 | -5 3 | 0.4009 3 | mentholic | |
| OR7D4 | 96 | - | 0.2 4 | animal, citrus, orange, peely, tart, aldehydic, blueberry | |
| OR8B8 | 100 | - | (probable agonist) 2 | ||
| OR8B12 | 92 | - | (probable agonist) 2 | ||
| OR5A1 | 100 | - | 0 5 | ||
| OR5A2 | 100 | - | 0 5 | ||
| OR5AN1 | 100 | - | 0 5 | ||
| OR7A17 | 100 | - | 0 6 |
(-)-menthol, l-menthol
SMILES:
C[C@@H]1CC[C@H]([C@@H](C1)O)C(C)C
Aroma Description:
peppermint, cooling, mentholic, minty, camphorous, cleanminty, fresh, sweet, herbal
| Receptor | Expr.% | Agonist? | Dock Score | Known agonist | Correlated Perceptual Qualities |
|---|
Dock Score is a measure of how strongly the algorithm thinks the odorant is likely to be an agonist of the receptor.
Receptors in italics are "orphans", i.e. receptors whose agonists have not been identified experimentally.
1.) The Good Scents Company
2.) Mengxue Wang, Fengge Wen, Lili Zhang, Baoguo Sun, Jianping Xie, Shihao Sun, and Yuyu Zhan. Decoding the Molecular Mechanisms of Menthol Isomer Perception Based on Computational Simulations. Foods 2025, 14(14), 2494
3.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.
4.) Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H. Genetic variation in a human odorant receptor alters odour perception. Nature. 2007 Sep 27;449(7161):468-72. doi: 10.1038/nature06162. Epub 2007 Sep 16. PMID: 17873857.
5.) Keiichi Yoshikawa, Jun Deguchi, Hu Jieying et al. Diverse yet selective tuning of an odorant receptor for sensing four classes of musk compounds, 03 August 2022, PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-1916850/v1]
6.) Dan Takase, Tomohiro Shirai, Kensuke Misawa, Hiroaki Matsunami, Keiichi Yoshikawa, An odorant receptor for a key odor constituent of ambergris. Communications Biology | (2025)8:792. doi: 10.1038/s42003-025-08229-y
7.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025
8.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1