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Olfactory Receptor family 1 subfamily D member 2.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MDGGNQSEGS EFLLLGMSES PEQQRILFWM FLSMYLVTVV GNVLIILAIS SDSRLHTPVY FFLANLSFTD LFFVTNTIPK MLVNLQSHNK AISYAGCLTQ 

       110        120        130        140        150        160        170        180        190        200 
LYFLVSLVAL DNLILAVMAY DRYVAICCPL HYTTAMSPKL CILLLSLCWV LSVLYGLIHT LLMTRVTFCG SRKIHYIFCE MYVLLRMACS NIQINHTVLI 

       210        220        230        240        250        260        270        280        290        300 
ATGCFIFLIP FGFVIISYVL IIRAILRIPS VSKKYKAFST CASHLGAVSL FYGTLCMVYL KPLHTYSVKD SVATVMYAVV TPMMNPFIYS LRNKDMHGAL 

       310        320 
GRLLDKHFKR LT

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

Q E P S   N V L   G A Y S     M L   I Q I N       K   K V S Y  
 I R Q   M K P I   T L C   L T H I   T H N   L Y V M   V S D   
M W F L   T N T   F Y L Q   L G Y   A I L V   C L T   M V T A  
 S L F   V F F L   S V L   L V S L   C G T   G Y F L   V A Y   
V L Y M   D T F   L A V L   V W C   L F I F   S V A   M P T V  
 V V T   S L N A   L N D   L S L L   F P I   G L H S   P N M   
L V N G   L F F   V A L I   L I C   I V F G   A C T   S Y I F  
 L I I   Y V P T   Y A M   L K P S   Y S I   S F A K           
S S I A           V Y R D           I I L V   Y K K            
                   C I A             I A R   S V S P           
                        C               R L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
bourgeonal -7.3 1 10 1  fresh, watery, floral, cyclamen, sweet
tetrahydromyrcenol -6.2 2 -  fresh, sweet, citrus, lime, floral, lily
floralozone -5.7 1 -  clean, fresh, green, marine, ozone
dihydromyrcenol -5.63 2 -  citrus, clean, cologne, floral, fresh, lime, weedy
citral dimethyl acetal -5.47 2 -  citrus, floral, green, lemon, lime, natural
dihydroisojasmonate -5.43 2 -  green, jasmine, floral, fresh, oily, herbal
(E),(E)-2,4-decadienal -5.18 2 -  brothy, chicken, citrus, coriander, cucumber, fat, fatty, fried, melon, nutty, oily, pumpkin
gamma-undecalactone -5.14 2 -  fruity, peach, creamy, fatty, lactonic, apricot, ketonic, coconut
myrcenol -5.12 2 -  fresh, floral, lavender, citrus
delta-dodecalactone -5.09 2 -  fresh, sweet, metallic, peach, oily, coconut, buttery, fatty, creamy, dairy, fruity, apricot, milky
coranol -4.96 2 -  bois_de_rose, coriander, floral, rose
zinarine -4.95 2 -  
rosaphen -4.87 2 -  floral, geranium, rose, waxy
benzyl acetone -4.86 2 -  floral, balsamic, strawberry
sulcatone -4.84 2 -  citrus, green, musty, lemongrass, apple, ketonic, creamy, cheesy, banana, vegetable, green_bean
tetrahydrolinalool -4.81 2 -  floral, lily, bois_de_rose, woody, lilac, tea, oily, fatty, citrus_rind
ethyl cinnamate -4.78 2 -  sweet, balsamic, fruity, spicy, powdery, berry, plum, cinnamyl, green
tetrahydrogeraniol -4.78 2 -  leathery, musty, plastic, rose, sweet
1-octyl-2-pyrrolidone -4.76 2 -  
pivarose -4.73 2 -  rose, spicy, red_rose, geranium, blueberry
mefrosol -4.66 2 -  floral, geranium, green, honey, lily, muguet, resh, rose, tropical
florymoss -4.54 2 -  
citral -4.52 2 -  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
delta-undecalactone -4.52 2 -  creamy, fatty, coconut, fruity, peach, waxy, milky, lactonic, green
(S)-(-)-citronellol -4.51 2 -  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
methyl cinnamate -4.49 2 -  balsamic, cherry, strawberry, sweet
milk lactone -4.49 2 -  waxy, buttery, oily, creamy, dairy, green, lactonic, plum_skin
(Z)-6-nonen-1-ol -4.48 2 -  cantaloupe, clean, cucumber, fatty, fresh, green, honeydew, juicy, melon, vegetable, waxy
(Z)-5-octen-1-ol -4.48 2 -  earthy, fishy, green, melon, mushroom, soapy, violet_leaf, watermelon, watery
ethyl linalool -4.47 2 -  bergamot, bois_de_rose, fresh, green, herbal, lavender, rose, wet
petiole -4.47 2 -  foliage, green, metallic, plastic, rose, spicy, watercress
1-octen-3-ol -4.38 2 -  mushroom
benzyl isobutyrate -4.31 2 -  jasmin, oily, fruity, sweet, rose, tropical, powdery, woody, juicy
7-octen-1-ol -4.3 2 -  
phenethyl isovalerate -4.3 2 -  floral, fruity, sweet, rose, peach, apricot, ripe, pineapple, tutti_frutti, apple, blueberry
isojasmone -4.26 2 -  creamy, fatty, floral, fruity, lactonic, spicy, waxy
linalool -4.26 2 -  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
1-nonanol -4.26 2 -  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
gamma-dodecalactone -4.25 2 -  fatty, fruity, metallic, peach, sweet
9-decen-1-ol -4.24 2 -  aldehydic, clean, dewy, floral, fresh, rose, waxy
ethyl p-anisate -4.24 2 -  anisic, cherry, floral, fruity, licorice, powdery, spicy, sweet, tarragon
nerolidyl acetate -4.21 2 -  fresh, sweet, citrus, waxy, freesia, woody
allyl cyclohexylpropionate -4.19 2 -  sweet, pineapple, tropical, fruity, candy, waxy, apple, green
muguet carbinol -4.19 2 -  bois_de_rose, clean, fresh, green, lily, rose, violet
(S)-(-)-citronellal -4.12 2 -  citrus, clean, herbal
jasmatone -4.12 2 -  floral, fruity, jasmine
3-methyl-3-nonanol -4.12 2 -  
benzyl butyrate -4.07 2 -  fresh, fruity, jasmine, apricot, loganberry, sweet, waxy, tropical, pineapple, apple
ethylene glycol monophenoxyacetate -4.06 2 -  
myrac aldehyde -4.02 2 -  aldehydic, citrus, floral, greasy, marine
geraniol -4 2 -  citrus, floral, fruity, rose, sweet, waxy
quintone -3.98 2 -  coconut, foliage, green, herbal, jasmine, oily, rose
benzyl propionate -3.95 2 -  sweet, fruity, floral, banana, jasmin, balsamic, apple, jammy
methyl tuberate -3.95 2 -  waxy, lactonic, metallic, tuberose, plum
benzyl acetate -3.94 2 -  sweet, floral, fruity, jasmine, fresh
beta-methylphenylethylamine -3.91 2 -  animalic
phenethyl acetate -3.91 2 -  floral, fruity, honey, rose, sweet, tropical
delta-tetradecalactone -3.9 2 -  waxy, creamy, buttery, oily, fatty, cheesy, milky, dairy
delta-2-decenolactone -3.86 2 -  sweet, creamy, coconut, lactonic, peach, fruity, herbal
(E)-2-nonenal -3.86 2 -  fatty, green, cucumber, aldehydic, citrus, soapy, melon
3-octyl acetate -3.86 2 -  fresh, bergamot, woody, green, grapefruit, rose, apple, minty, waxy, aldehydic, fatty, citrus, anisic
5-decanol -3.85 2 -  clean, fatty, floral, orange, sweet, watery, waxy
2-heptanone -3.78 2 -  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
citronellyl oxyacetaldehyde -3.77 2 -  aldehydic, floral, fresh, honeysuckle, muguet, sweet, waxy
gamma-decalactone -3.75 2 -  fresh, oily, waxy, peach, coconut, buttery, sweet
7-methylindole -3.75 2 -  
gamma-nonalactone -3.64 2 -  buttery, coconut, creamy, oily, sweet, waxy
phenoxyethyl isobutyrate -3.56 2 -  sweet, fruity, tropical, rose, honey, floral, waxy, green, apple, powdery
5-methylindole -3.53 2 -  
cinnamyl alcohol -3.47 2 -  balsamic, cinnamon, cinnamyl, fermented, floral, green, hyacinth, powdery, spicy, sweet
strawberry glycidate -3.43 2 -  cherry, fruity, grape, jammy, phenolic, strawberry, sweet
anisyl acetate -3.38 2 -  sweet, powdery, balsamic, vanilla, fruity, plum, cherry, tonka, creamy, spicy, coumarinic, licorice
geranyl formate -3.31 2 -  apple, floral, fresh, fruity, green, neroli, peach, rose, tea, tropical
octanal -3.29 2 -  aldehydic, citrus, fatty, green, orange, peel, waxy
neryl acetate -3.25 2 -  citrus, dewy, floral, fruity, grapefruit, pear, rose, soapy, sweet, tropical
delta-nonalactone -3.19 2 -  coconut, creamy, sweet, milky, coumarinic, fatty, oily
delta-tridecalactone -3.14 2 -  buttery, creamy, dairy, milky, musty, oily
geranyl propionate -3.1 2 -  floral, waxy, fruity, rose, tropical, citrus, geranium, powdery, honey, vegetable
acetanisole -3.09 2 -  sweet, hawthorn, anisic, powdery, balsamic, acacia, vanilla, maraschino_cherry, fruity, cherry
tetrahydro citral -3.05 2 -  aldehydic, citrus, green, lemon
delta-decalactone -2.99 2 -  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
oranger crystals -4.67 2 2.0588 3  sweet, neroli, orangeflower, powdery, honey, floral, orange, naphthyl, citrus
geranyl butyrate -2.96 2 -  apricot, fresh, fruity, green, peach, raspberry, rose, sweet, tropical, waxy
lilial -5.7 1 0.2129 4  floral, muguet, watery, green, powdery, cumin
1-methylindole -2.89 2 -  
heptanal -2.71 2 -  aldehydic, cognac, fatty, fresh, green, herbal, ozone
methyl nicotinate -2.7 2 -  warm, herbal, tobacco
geranyl acetate -4 4 0.9405 4  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
nonanal -1.71 2 -  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
diethyleneglycol hexyl ether -1.52 2 -  
3-octen-2-one - 1 5  earthy, spicy, herbal, sweet, mushroom, hay, blueberry
cinnamyl nitrile - 0 2  cinnamon, cassia, spicy, cumin
citronellyl nitrile - 0 2  citrus, floral, fresh, lemon, metallic, waxy
clonal - 0 2  dry, citrus, orange_peel, metallic, spicy
floridile - 0 2  
frutonile - 0 2  floral, fruity, jasmine, lactonic, peach
hypo-lem - 0 2  citrus, aldehydic, lemon, fatty, metallic
sulfuryl acetate - 0 1  meaty, beef, juice, beefy
undecanal - 0 1 Yaldehydic, citrus, cloth, fatty, floral, green, laundered, soapy, waxy
undecene-2-nitrile - 0 2  
violet nitrile - 0 2  floral, green, leaf, violet, walnut

1.) B.L. Cook, D. Steuerwald, L. Kaiser, J. Graveland-Bikker, M. Vanberghem, A.P. Berke, K. Herlihy, H. Pick, H. Vogel, S. Zhang, Large-scale production and study of a synthetic G protein-coupled receptor: Human olfactory receptor 17-4, Proc. Natl. Acad. Sci. USA 106 (2009) 11925-11930

2.) Veithen, A.; Wilin, F.; Philippeau, M.; Chatelain, P. OR1D2 is a broadly tuned human olfactory receptor. Chem. Senses 2015, 40, 262–263.

3.) Ieki T, Yamanaka Y, Yoshikawa K (2022) Functional analysis of human olfactory receptors with a high basal activity using LNCaP cell line. PLOS ONE 17(4): e0267356.

4.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

5.) Motoki Yasunaga, Eiji Takai, Shoji Hattori, Kenji Tatematsu, Shun'ichi Kuroda, Effects of 3-octen-2-one on human olfactory receptor responses to vanilla flavor, Bioscience, Biotechnology, and Biochemistry, 2022;, zbac147, https://doi.org/10.1093/bbb/zbac147
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